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    Ecsit ECSIT signaling integrator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300447, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ecsitprovided by RGD
    Official Full Name
    ECSIT signaling integratorprovided by RGD
    Primary source
    RGD:1359488
    See related
    EnsemblRapid:ENSRNOG00000014128 AllianceGenome:RGD:1359488
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription factor activity; chromatin binding activity; and molecular adaptor activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; innate immune response; and regulation of protein complex stability. Predicted to act upstream of or within BMP signaling pathway; mesoderm formation; and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in mitochondrion. Orthologous to human ECSIT (ECSIT signaling integrator). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 551.4), Muscle (RPKM 452.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ecsit in Genome Data Viewer
    Location:
    8q13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (28881594..28894443, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (20605583..20618453, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (23085598..23099064, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ELAV like RNA binding protein 3 Neighboring gene zinc finger protein 653 Neighboring gene uncharacterized LOC120094091 Neighboring gene calponin 1 Neighboring gene elongation factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly. Vogel RO, et al. Genes Dev, 2007 Mar 1. PMID 17344420, Free PMC Article
    2. TRIM59 interacts with ECSIT and negatively regulates NF-κB and IRF-3/7-mediated signal pathways. Kondo T, et al. Biochem Biophys Res Commun, 2012 Jun 8. PMID 22588174
    3. Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Xiao C, et al. Genes Dev, 2003 Dec 1. PMID 14633973, Free PMC Article
    4. ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Kopp E, et al. Genes Dev, 1999 Aug 15. PMID 10465784, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC94704

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell surface receptor protein serine/threonine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mesoderm formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of oxidoreductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of protein complex stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein complex stability ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in toll-like receptor 4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
    Names
    ECSIT homolog
    ECSIT signalling integrator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006986.1 → NP_001006987.1  evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001006987.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083762
      UniProtKB/Swiss-Prot
      Q5XIC2
      UniProtKB/TrEMBL
      A0A8I5ZQV7, A6JNY0
      Related
      ENSRNOP00000019115.3, ENSRNOT00000019115.7
      Conserved Domains (3) summary
      sd00004
      Location:125 → 170
      PPR; PPR repeat [structural motif]
      pfam06239
      Location:49 → 265
      ECSIT; Evolutionarily conserved signalling intermediate in Toll pathway
      pfam14784
      Location:268 → 392
      ECSIT_C; C-terminal domain of the ECSIT protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      28881594..28894443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242636.5 → XP_006242698.1  evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006242698.1

      UniProtKB/TrEMBL
      A0A8I5ZQV7
      Conserved Domains (3) summary
      sd00004
      Location:125 → 170
      PPR; PPR repeat [structural motif]
      pfam06239
      Location:49 → 271
      ECSIT; Evolutionarily conserved signalling intermediate in Toll pathway
      pfam14784
      Location:274 → 398
      ECSIT_C; C-terminal domain of the ECSIT protein

    2. XM_006242637.5 → XP_006242699.1  evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006242699.1

      UniProtKB/TrEMBL
      A0A8I5ZQV7
      Conserved Domains (3) summary
      sd00004
      Location:125 → 170
      PPR; PPR repeat [structural motif]
      pfam06239
      Location:49 → 271
      ECSIT; Evolutionarily conserved signalling intermediate in Toll pathway
      pfam14784
      Location:274 → 398
      ECSIT_C; C-terminal domain of the ECSIT protein

    3. XM_006242638.5 → XP_006242700.1  evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006242700.1

      UniProtKB/Swiss-Prot
      Q5XIC2
      UniProtKB/TrEMBL
      A0A8I5ZQV7, A6JNY0
      Conserved Domains (3) summary
      sd00004
      Location:125 → 170
      PPR; PPR repeat [structural motif]
      pfam06239
      Location:49 → 265
      ECSIT; Evolutionarily conserved signalling intermediate in Toll pathway
      pfam14784
      Location:268 → 392
      ECSIT_C; C-terminal domain of the ECSIT protein

    4. XM_039081013.2 → XP_038936941.1  evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X2

      UniProtKB/Swiss-Prot
      Q5XIC2
      UniProtKB/TrEMBL
      A0A8I5ZQV7, A6JNY0
      Conserved Domains (3) summary
      sd00004
      Location:125 → 170
      PPR; PPR repeat [structural motif]
      pfam06239
      Location:49 → 265
      ECSIT; Evolutionarily conserved signalling intermediate in Toll pathway
      pfam14784
      Location:268 → 392
      ECSIT_C; C-terminal domain of the ECSIT protein

    5. XM_039081012.2 → XP_038936940.1  evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQV7
      Conserved Domains (3) summary
      sd00004
      Location:125 → 170
      PPR; PPR repeat [structural motif]
      pfam06239
      Location:49 → 271
      ECSIT; Evolutionarily conserved signalling intermediate in Toll pathway
      pfam14784
      Location:274 → 398
      ECSIT_C; C-terminal domain of the ECSIT protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIC2.1 GenPept UniProtKB/Swiss-Prot:Q5XIC2

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