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    Acot6 acyl-CoA thioesterase 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299193, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Acot6provided by RGD
    Official Full Name
    acyl-CoA thioesterase 6provided by RGD
    Primary source
    RGD:1309669
    See related
    AllianceGenome:RGD:1309669
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309669
    Summary
    Predicted to enable acyl-CoA hydrolase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid metabolic process. Predicted to be located in cytosol. Orthologous to human ACOT6 (acyl-CoA thioesterase 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 4.7), Heart (RPKM 3.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Acot6 in Genome Data Viewer
    Location:
    6q31
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (109463513..109472587)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (103732372..103741446)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (107581357..107590431)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479230 Neighboring gene acyl-CoA thioesterase 5, pseudogene 1 Neighboring gene uncharacterized LOC134479231 Neighboring gene dynein, axonemal, light chain 1 Neighboring gene uncharacterized LOC120103573 Neighboring gene PNMA family member 1 Neighboring gene mitotic deacetylase associated SANT domain protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. Hunt MC, et al. FASEB J, 2006 Sep. PMID 16940157
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables fatty acyl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    acyl-coenzyme A thioesterase 6
    NP_001292214.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305285.1 → NP_001292214.1  acyl-coenzyme A thioesterase 6

      See identical proteins and their annotated locations for NP_001292214.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6JDT1, D3ZSE3
      Conserved Domains (3) summary
      COG0657
      Location:83 → 373
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam04775
      Location:17 → 137
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
      pfam08840
      Location:203 → 413
      BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      109463513..109472587
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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