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    Tenm1 teneurin transmembrane protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298168, updated on 18-Sep-2024

    Summary

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    Symbol
    Tenm1provided by RGD
    Full Name
    teneurin transmembrane protein 1provided by RGD
    Primary source
    RGD:1561678
    See related
    EnsemblRapid:ENSRNOG00000062454 AllianceGenome:RGD:1561678
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Odz1; RGD1561678
    Summary
    Predicted to enable protein heterodimerization activity and protein homodimerization activity. Predicted to be involved in positive regulation of cellular component biogenesis; positive regulation of protein phosphorylation; and regulation of transcription by RNA polymerase III. Predicted to be located in several cellular components, including extracellular region; nucleus; and perinuclear region of cytoplasm. Predicted to be integral component of plasma membrane. Orthologous to human TENM1 (teneurin transmembrane protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 135.8), Thymus (RPKM 63.6) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tenm1 in Genome Data Viewer
    Location:
    Xq35
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (126265968..127155737, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (121400466..122289877, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (129034755..129336023, complement) , (128923951..128951520, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene estrogen receptor binding site associated, antigen, 9, pseudogene 1 Neighboring gene testis-expressed protein 13D-like Neighboring gene SH2 domain containing 1A Neighboring gene small nucleolar RNA SNORA17 Neighboring gene 60S ribosomal protein L23 pseudogene Neighboring gene uncharacterized LOC134484114 Neighboring gene mitochondrial ribosomal protein S36 like 1 Neighboring gene TEX13 family member C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. C-terminal processing of the teneurin proteins: independent actions of a teneurin C-terminal associated peptide in hippocampal cells. Chand D, et al. Mol Cell Neurosci, 2013 Jan. PMID 23026563
    2. Repeated intracerebral teneurin C-terminal associated peptide (TCAP)-1 injections produce enduring changes in behavioral responses to corticotropin-releasing factor (CRF) in rat models of anxiety. Tan LA, et al. Behav Brain Res, 2008 Mar 17. PMID 18082275
    3. C-Terminal region of teneurin-1 co-localizes with dystroglycan and modulates cytoskeletal organization through an extracellular signal-regulated kinase-dependent stathmin- and filamin A-mediated mechanism in hippocampal cells. Chand D, et al. Neuroscience, 2012 Sep 6. PMID 22698694
    4. Identification of a novel brain derived neurotrophic factor (BDNF)-inhibitory factor: regulation of BDNF by teneurin C-terminal associated peptide (TCAP)-1 in immortalized embryonic mouse hypothalamic cells. Ng T, et al. Regul Pept, 2012 Feb 10. PMID 22209827
    5. Mouse ten-m/Odz is a new family of dimeric type II transmembrane proteins expressed in many tissues. Oohashi T, et al. J Cell Biol, 1999 May 3. PMID 10225957, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In the plus maze and open field tests, acute CRF effects were enhanced by prior TCAP-1 treatment, whereas in the acoustic startle test, the acute CRF effects were diminished by prior TCAP-1 administration [TCAP-1]
      Title: Repeated intracerebral teneurin C-terminal associated peptide (TCAP)-1 injections produce enduring changes in behavioral responses to corticotropin-releasing factor (CRF) in rat models of anxiety.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase III ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    teneurin-1
    Names
    protein Odd Oz/ten-m homolog 1
    teneurin-1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      126265968..127155737 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063280507.1 → XP_063136577.1  teneurin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AQ34

    2. XM_063280510.1 → XP_063136580.1  teneurin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AQ34

    3. XM_039100433.2 → XP_038956361.1  teneurin-1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AQ34
      Related
      ENSRNOP00000100767.1, ENSRNOT00000135707.1
      Conserved Domains (9) summary
      COG3209
      Location:1823 → 2392
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1195 → 1234
      NHL; NHL repeat [structural motif]
      cl18310
      Location:1195 → 1526
      NHL; NHL repeat unit of beta-propeller proteins
      pfam05593
      Location:1642 → 1674
      RHS_repeat; RHS Repeat
      pfam06484
      Location:23 → 317
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2646 → 2723
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033662
      Location:801 → 826
      acid_disulf_rpt; acidic double-disulfide repeat
      NF033759
      Location:533 → 741
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:709 → 750
      DSL; Delta serrate ligand

    4. XM_063280511.1 → XP_063136581.1  teneurin-1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AQ34

    5. XM_039100429.2 → XP_038956357.1  teneurin-1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y571, A0A8I6AQ34
      Related
      ENSRNOP00000076979.1, ENSRNOT00000100607.2
      Conserved Domains (9) summary
      COG3209
      Location:1824 → 2393
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:1196 → 1235
      NHL; NHL repeat [structural motif]
      cl18310
      Location:1196 → 1527
      NHL; NHL repeat unit of beta-propeller proteins
      pfam05593
      Location:1643 → 1675
      RHS_repeat; RHS Repeat
      pfam06484
      Location:23 → 317
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:2647 → 2724
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033662
      Location:802 → 827
      acid_disulf_rpt; acidic double-disulfide repeat
      NF033759
      Location:534 → 742
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:710 → 751
      DSL; Delta serrate ligand

    6. XM_063280506.1 → XP_063136576.1  teneurin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AQ34
      Related
      ENSRNOP00000104343.1, ENSRNOT00000143389.1

    7. XM_063280509.1 → XP_063136579.1  teneurin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AQ34

    8. XM_063280508.1 → XP_063136578.1  teneurin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AQ34
    Nucleotide Protein Strain
    Heading Accession and Version

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