Tapbpl TAP binding protein-like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tapbplprovided by RGD
Official Full Name: TAP binding protein-likeprovided by RGD
Primary source: RGD:1307893
See related: EnsemblRapid:ENSRNOG00000077779 AllianceGenome:RGD:1307893
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable MHC class I protein complex binding activity and TAP complex binding activity. Predicted to be involved in negative regulation of antigen processing and presentation of peptide antigen via MHC class I and peptide antigen assembly with MHC class I protein complex. Predicted to be located in endoplasmic reticulum. Predicted to be part of MHC class I peptide loading complex. Orthologous to human TAPBPL (TAP binding protein like). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 182.5), Adrenal (RPKM 148.9) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 4q42

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (159707686..159715137, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (158021454..158028905, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (157735748..157743199, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables MHC class I protein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables MHC class I protein complex binding	ISO Inferred from Sequence Orthology more info
enables TAP complex binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of antigen processing and presentation of peptide antigen via MHC class I	ISO Inferred from Sequence Orthology more info
involved_in peptide antigen assembly with MHC class I protein complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptide antigen assembly with MHC class I protein complex	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of MHC class I peptide loading complex	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: tapasin-related protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106622.1 → NP_001100092.1 tapasin-related protein precursor

See identical proteins and their annotated locations for NP_001100092.1

Status: PROVISIONAL

Source sequence(s)

CH473964

UniProtKB/TrEMBL

A6ILT2

Related

ENSRNOP00000100879.1, ENSRNOT00000166679.1

Conserved Domains (3) summary

smart00410
Location:205 → 301

IG_like; Immunoglobulin like

pfam07686
Location:205 → 302

V-set; Immunoglobulin V-set domain

cl11960
Location:267 → 397

Ig; Immunoglobulin domain