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    Srsf5 serine and arginine rich splicing factor 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29667, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Srsf5provided by RGD
    Official Full Name
    serine and arginine rich splicing factor 5provided by RGD
    Primary source
    RGD:3664
    See related
    EnsemblRapid:ENSRNOG00000005513 AllianceGenome:RGD:3664
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    HRS; SRp40; Sfrs5
    Summary
    Enables RNA binding activity and protein kinase B binding activity. Involved in cellular response to insulin stimulus; liver regeneration; and positive regulation of RNA splicing. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in nuclear speck. Orthologous to human SRSF5 (serine and arginine rich splicing factor 5). [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Note: Due to a potential assembly artifact, Rattus norvegicus Annotation Release 105 annotates the 5' end of this gene on chromosome 6 (NW_007905843.1) and the 3' end on chromosome 17 (NW_007906018.1) on Rnor_6.0. The correct location of this gene is on chromosome 6. [04 Mar 2016]
    Expression
    Biased expression in Thymus (RPKM 1138.7), Lung (RPKM 906.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Srsf5 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (106333998..106341467)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (100605165..100610192)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (104611026..104640033)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene pleckstrin homology and coiled-coil domain containing D1 Neighboring gene coiled-coil domain containing 177 Neighboring gene sushi domain containing 6 Neighboring gene solute carrier family 10 member 1 Neighboring gene phospholipase A2 group IB like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. HRS/SRp40-mediated inclusion of the fibronectin EIIIB exon, a possible cause of increased EIIIB expression in proliferating liver. Du K, et al. Mol Cell Biol, 1997 Jul. PMID 9199345, Free PMC Article
    2. Increased expression of SRp40 affecting CD44 splicing is associated with the clinical outcome of lymph node metastasis in human breast cancer. Huang CS, et al. Clin Chim Acta, 2007 Sep. PMID 17651715
    3. Novel delayed-early and highly insulin-induced growth response genes. Identification of HRS, a potential regulator of alternative pre-mRNA splicing. Diamond RH, et al. J Biol Chem, 1993 Jul 15. PMID 7686911
    4. Alternative splicing and structure of the human and mouse SFRS5/HRS/SRp40 genes. Du K, et al. Gene, 1997 Dec 19. PMID 9434190
    5. Altered expression of heterogenous nuclear ribonucleoproteins and SR factors in human colon adenocarcinomas. Ghigna C, et al. Cancer Res, 1998 Dec 15. PMID 9865741

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RS domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase B binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to insulin stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in liver development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in liver regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to insulin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to insulin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/arginine-rich splicing factor 5
    Names
    delayed-early protein HRS
    insulin-induced growth response protein CL-4
    pre-mRNA-splicing factor SRP40
    splicing factor, arginine/serine-rich 5 (SRp40, HRS)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195505.1 → NP_001182434.1  serine/arginine-rich splicing factor 5

      See identical proteins and their annotated locations for NP_001182434.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      BC058479, BE115959, FM049719, FM081441
      UniProtKB/Swiss-Prot
      O35335, Q09167
      UniProtKB/TrEMBL
      A6JDK6
      Conserved Domains (2) summary
      cd12595
      Location:5 → 74
      RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
      cd12765
      Location:99 → 179
      RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)

    2. NM_001195506.1 → NP_001182435.1  serine/arginine-rich splicing factor 5

      See identical proteins and their annotated locations for NP_001182435.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      BC058479, BE115959, FM059586, FM081441
      UniProtKB/Swiss-Prot
      O35335, Q09167
      UniProtKB/TrEMBL
      A6JDK6
      Conserved Domains (2) summary
      cd12595
      Location:5 → 74
      RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
      cd12765
      Location:99 → 179
      RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)

    3. NM_019257.3 → NP_062130.2  serine/arginine-rich splicing factor 5

      See identical proteins and their annotated locations for NP_062130.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      BC058479, BE115959, FM081441
      UniProtKB/Swiss-Prot
      O35335, Q09167
      UniProtKB/TrEMBL
      A6JDK6
      Conserved Domains (2) summary
      cd12595
      Location:5 → 74
      RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
      cd12765
      Location:99 → 179
      RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      106333998..106341467
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111859.2 → XP_038967787.1  serine/arginine-rich splicing factor 5 isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q2R9
      Conserved Domains (2) summary
      cd12595
      Location:5 → 74
      RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
      cd12765
      Location:99 → 179
      RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)

    2. XM_063261587.1 → XP_063117657.1  serine/arginine-rich splicing factor 5 isoform X2

      UniProtKB/Swiss-Prot
      O35335, Q09167
      UniProtKB/TrEMBL
      A6JDK6

    3. XM_039111856.2 → XP_038967784.1  serine/arginine-rich splicing factor 5 isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q2R9
      Related
      ENSRNOP00000087250.2, ENSRNOT00000107441.2
      Conserved Domains (2) summary
      cd12595
      Location:5 → 74
      RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
      cd12765
      Location:99 → 179
      RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)

    4. XM_039111857.2 → XP_038967785.1  serine/arginine-rich splicing factor 5 isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q2R9
      Conserved Domains (2) summary
      cd12595
      Location:5 → 74
      RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
      cd12765
      Location:99 → 179
      RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)

    5. XM_039111858.2 → XP_038967786.1  serine/arginine-rich splicing factor 5 isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q2R9
      Conserved Domains (2) summary
      cd12595
      Location:5 → 74
      RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
      cd12765
      Location:99 → 179
      RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)

    6. XM_063261591.1 → XP_063117661.1  serine/arginine-rich splicing factor 5 isoform X5

      UniProtKB/TrEMBL
      A6JDK8

    7. XM_063261589.1 → XP_063117659.1  serine/arginine-rich splicing factor 5 isoform X5

      UniProtKB/TrEMBL
      A6JDK8

    8. XM_063261590.1 → XP_063117660.1  serine/arginine-rich splicing factor 5 isoform X5

      UniProtKB/TrEMBL
      A6JDK8

    9. XM_039111860.2 → XP_038967788.1  serine/arginine-rich splicing factor 5 isoform X3

      Conserved Domains (1) summary
      cl17169
      Location:4 → 61
      RRM_SF; RNA recognition motif (RRM) superfamily

    10. XM_063261588.1 → XP_063117658.1  serine/arginine-rich splicing factor 5 isoform X4

    RNA

    1. XR_010052053.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09167.1 GenPept UniProtKB/Swiss-Prot:Q09167

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