U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Ap1b1 adaptor related protein complex 1 subunit beta 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29663, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ap1b1provided by RGD
    Official Full Name
    adaptor related protein complex 1 subunit beta 1provided by RGD
    Primary source
    RGD:2064
    See related
    EnsemblRapid:ENSRNOG00000008786 AllianceGenome:RGD:2064
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Adtb1
    Summary
    Enables protein serine/threonine kinase binding activity. Involved in clathrin coat assembly. Predicted to be located in Golgi apparatus and cytosol. Predicted to be part of clathrin coat. Predicted to be active in synaptic vesicle. Orthologous to human AP1B1 (adaptor related protein complex 1 subunit beta 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 235.1), Brain (RPKM 218.7) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ap1b1 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (84093529..84144835)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (79879482..79930778)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (85230652..85281806)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene neurofilament heavy chain Neighboring gene uncharacterized LOC134481867 Neighboring gene small nucleolar RNA, C/D box 125 Neighboring gene uncharacterized LOC120096647 Neighboring gene RAS-like, family 10, member A Neighboring gene growth arrest-specific 2 like 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Direct effects of the angiotensin-converting enzyme inhibitor ramiprilat on adult rat ventricular cardiomyocytes. Helmig S, et al. Acta Physiol (Oxf), 2007 Dec. PMID 17825088
    2. Alternate pathways preserve tumor necrosis factor-alpha production after nuclear factor-kappaB inhibition in neonatal cerebral hypoxia-ischemia. Nijboer CH, et al. Stroke, 2009 Oct. PMID 19628795
    3. Matrix metalloproteinase-3 induction in rat brain astrocytes: focus on the role of two AP-1 elements. Kim KS, et al. Biochem J, 2008 Mar 15. PMID 18072934
    4. Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene. Peyrard M, et al. Hum Mol Genet, 1994 Aug. PMID 7987321
    5. Effect of short term calorie restriction on pro-inflammatory NF-kB and AP-1 in aged rat kidney. Jung KJ, et al. Inflamm Res, 2009 Mar. PMID 19199090

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our data indicate that the switch to JNK/AP-1 activation preserves HI-induced TNF-alpha expression and thereby might contribute to the neuroprotective effect of TAT-NBD possibly through a TNF-R2 dependent mechanism.
      Title: Alternate pathways preserve tumor necrosis factor-alpha production after nuclear factor-kappaB inhibition in neonatal cerebral hypoxia-ischemia.
    2. Results suggest that 10-day calorie restriction can attenuate the altered signal transduction for inflammatory processes which is mediated through reactive species-induced NF-kB and AP-1 in aged kidney.
      Title: Effect of short term calorie restriction on pro-inflammatory NF-kB and AP-1 in aged rat kidney.
    3. results indicate that AP-1 could control MMP-3 induction in brain astrocytes and that its regulation through specific AP-1 elements could be exploited in the treatment of brain pathologies in which increased expression of MMP-3 plays crucial roles
      Title: Matrix metalloproteinase-3 induction in rat brain astrocytes: focus on the role of two AP-1 elements.
    4. Ramiprilat exerts direct, bradykinin-receptor independent effects on cardiomyocytes that improve cellular function without a corresponding effect on AP-1 activation or induction of AP-1 dependent effects.
      Title: Direct effects of the angiotensin-converting enzyme inhibitor ramiprilat on adult rat ventricular cardiomyocytes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables clathrin binding IC
    Inferred by Curator
    more info
    		 PubMed 
    enables clathrin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in clathrin coat assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in determination of left/right symmetry IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within determination of left/right symmetry ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heart development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in kidney development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within kidney development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of clathrin coat IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in clathrin-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    AP-1 complex subunit beta-1
    Names
    adaptor-related protein complex 1, beta 1 subunit
    adaptor-related protein complex AP-1 beta 1 subunit
    beta-adaptin 1
    clathrin assembly protein complex 1 beta large chain
    golgi adaptor HA1/AP1 adaptin beta subunit

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308298.1 → NP_001295227.1  AP-1 complex subunit beta-1

      See identical proteins and their annotated locations for NP_001295227.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      P52303
      UniProtKB/TrEMBL
      A0A0G2K2V2, A6IKJ5
      Related
      ENSRNOP00000072388.3, ENSRNOT00000089866.3
      Conserved Domains (5) summary
      smart00809
      Location:729 → 829
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:838 → 948
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region
      pfam12717
      Location:99 → 268
      Cnd1; non-SMC mitotic condensation complex subunit 1
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      84093529..84144835
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273010.1 → XP_063129080.1  AP-1 complex subunit beta-1 isoform X2

      UniProtKB/TrEMBL
      A6IKJ6, G3V9N8

    2. XM_063273009.1 → XP_063129079.1  AP-1 complex subunit beta-1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K2V2, A6IKJ5

    3. XM_063273008.1 → XP_063129078.1  AP-1 complex subunit beta-1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K2V2, A6IKJ5
      Related
      ENSRNOP00000054218.6, ENSRNOT00000057407.6

    4. XM_039091797.2 → XP_038947725.1  AP-1 complex subunit beta-1 isoform X2

      UniProtKB/Swiss-Prot
      P52303
      UniProtKB/TrEMBL
      A6IKJ6, G3V9N8
      Related
      ENSRNOP00000096766.1, ENSRNOT00000115824.2
      Conserved Domains (4) summary
      smart00809
      Location:722 → 822
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:831 → 941
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region

    5. XM_063273011.1 → XP_063129081.1  AP-1 complex subunit beta-1 isoform X2

      UniProtKB/TrEMBL
      A6IKJ6, G3V9N8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52303.1 GenPept UniProtKB/Swiss-Prot:P52303

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools