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    Msh4 mutS homolog 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295541, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Msh4provided by RGD
    Official Full Name
    mutS homolog 4provided by RGD
    Primary source
    RGD:1309190
    See related
    EnsemblRapid:ENSRNOG00000010431 AllianceGenome:RGD:1309190
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable double-stranded DNA binding activity. Predicted to be involved in reciprocal meiotic recombination. Predicted to act upstream of or within several processes, including homologous chromosome pairing at meiosis; ovarian follicle development; and spermatogenesis. Predicted to be located in recombination nodule and synaptonemal complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in primary ovarian insufficiency and spermatogenic failure 2. Orthologous to human MSH4 (mutS homolog 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 20.4) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Msh4 in Genome Data Viewer
    Location:
    2q45
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (245445118..245504493, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (242785392..242844609, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (260057708..260108897, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103691740 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ankyrin repeat and SOCS box-containing 17 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA, C/D box 45B Neighboring gene small nucleolar RNA, C/D box 45A Neighboring gene Rab geranylgeranyltransferase subunit beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Novel and diverse functions of the DNA mismatch repair family in mammalian meiosis and recombination. Kolas NK, et al. Cytogenet Genome Res, 2004. PMID 15467367
    2. Mouse HFM1/Mer3 is required for crossover formation and complete synapsis of homologous chromosomes during meiosis. Guiraldelli MF, et al. PLoS Genet, 2013 Mar. PMID 23555294, Free PMC Article
    3. Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I. Kolas NK, et al. J Cell Biol, 2005 Nov 7. PMID 16260499, Free PMC Article
    4. MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice. Kneitz B, et al. Genes Dev, 2000 May 1. PMID 10809667, Free PMC Article
    5. Alignment of Homologous Chromosomes and Effective Repair of Programmed DNA Double-Strand Breaks during Mouse Meiosis Require the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein. Finsterbusch F, et al. PLoS Genet, 2016 Oct. PMID 27760146, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional characterization of the mouse Msh4 ortholog.
      Title: MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mismatched DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within female gamete generation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within homologous chromosome pairing at meiosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within meiotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mismatch repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in condensed chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in condensed nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recombination nodule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptonemal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mutS protein homolog 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106477.3 → NP_001099947.2  mutS protein homolog 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      F1M9U4
      Related
      ENSRNOP00000014106.5, ENSRNOT00000014106.7
      Conserved Domains (1) summary
      COG0249
      Location:121 → 861
      MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      245445118..245504493 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102112.2 → XP_038958040.1  mutS protein homolog 4 isoform X1

      UniProtKB/TrEMBL
      F1M9U4
      Conserved Domains (1) summary
      COG0249
      Location:121 → 861
      MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]

    2. XM_063281671.1 → XP_063137741.1  mutS protein homolog 4 isoform X2

    3. XM_039102113.2 → XP_038958041.1  mutS protein homolog 4 isoform X2

      Conserved Domains (1) summary
      COG0249
      Location:1 → 520
      MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]

    4. XM_039102114.2 → XP_038958042.1  mutS protein homolog 4 isoform X3

      Conserved Domains (1) summary
      COG0249
      Location:23 → 411
      MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]

    RNA

    1. XR_010063597.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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