Nodal nodal growth differentiation factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nodalprovided by RGD
Official Full Name: nodal growth differentiation factorprovided by RGD
Primary source: RGD:1305994
See related: EnsemblRapid:ENSRNOG00000000556 AllianceGenome:RGD:1305994
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cytokine activity and type I activin receptor binding activity. Predicted to be involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to act upstream of or within several processes, including animal organ development; embryonic morphogenesis; and regulation of embryonic development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human NODAL (nodal growth differentiation factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 1.2), Testes (RPKM 0.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (29911258..29919659)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (29368436..29376837)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (31035729..31044096)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of EBAF/Nodal/p27 signaling pathway in development of placenta in normal and diabetic rats.
Title: Role of EBAF/Nodal/p27 signaling pathway in development of placenta in normal and diabetic rats.
Nodal mitigates cerebral ischemia-reperfusion injury via inhibiting oxidative stress and inflammation.
Title: Nodal mitigates cerebral ischemia-reperfusion injury via inhibiting oxidative stress and inflammation.
These observations have shed new light on the relevance of the NODAL/LEFTY2 pathway in the oviduct during early embryo development and the role of the embryo in modulating this pathway.
Title: Embryo presence regulates NODAL/LEFTY2 system in the rat oviduct in vivo.
Data suggest that up-regulation of Nodal expression increases apoptosis of beta cells and is associated with increased Alk7 expression, activation of Smad3 signaling, and down-regulation of apoptosis regulatory proteins.
Title: Nodal induces apoptosis through activation of the ALK7 signaling pathway in pancreatic INS-1 β-cells.
Regulation of nodal/activin receptor-like kinase 7 signaling pathway play a role in the control of ovarian follicular atresia.
Title: Role and regulation of nodal/activin receptor-like kinase 7 signaling pathway in the control of ovarian follicular atresia.

Submit: New GeneRIF Correction

General gene information

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Markers

Nodal (e-PCR), detects polymorphism
- UniSTS:144035

Nodal (e-PCR), detects polymorphism
- UniSTS:532680

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables type I activin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anatomical structure formation involved in morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within anterior/posterior axis specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axial mesodermal cell fate specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell fate commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell migration involved in gastrulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in determination of left/right asymmetry in lateral mesoderm	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within determination of left/right symmetry	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within digestive system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within digestive tract morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic heart tube development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic pattern specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic placenta development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic process involved in female pregnancy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endoderm development	ISO Inferred from Sequence Orthology more info
involved_in endodermal cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within floor plate morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within formation of anatomical boundary	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gastrulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gastrulation with mouth forming second	ISO Inferred from Sequence Orthology more info
acts_upstream_of germ cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart looping	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inhibition of neuroepithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within left lung morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within liver development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within maternal placenta development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within maternal process involved in parturition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesendoderm development	ISO Inferred from Sequence Orthology more info
involved_in mesendoderm development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesoderm formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chorionic trophoblast cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of reproductive process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of trophoblast cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural fold formation	ISO Inferred from Sequence Orthology more info
involved_in nodal signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in placenta development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within polarity specification of proximal/distal axis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within primitive streak formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gastrulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within somatic stem cell population maintenance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within stem cell population maintenance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tissue morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within trophectodermal cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within trophectodermal cellular morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculature development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nodal homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106394.1 → NP_001099864.1 nodal homolog precursor

See identical proteins and their annotated locations for NP_001099864.1

Status: PROVISIONAL

Source sequence(s)

CH474016

UniProtKB/TrEMBL

A6K3Z7, D3ZGK9

Related

ENSRNOP00000000672.2, ENSRNOT00000000672.6

Conserved Domains (2) summary

cd13759
Location:252 → 353

TGF_beta_NODAL; transforming growth factor beta (TGF-beta) like domain found in Nodal (NODAL)-related proteins

cl02928
Location:29 → 168

TGFb_propeptide; TGF-beta propeptide