Trpm6 transient receptor potential cation channel, subfamily M, member 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trpm6provided by RGD
Official Full Name: transient receptor potential cation channel, subfamily M, member 6provided by RGD
Primary source: RGD:1309942
See related: EnsemblRapid:ENSRNOG00000013053 AllianceGenome:RGD:1309942
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cation channel activity. Predicted to be involved in cation transmembrane transport and response to toxic substance. Predicted to act upstream of or within metal ion transport. Predicted to be located in brush border membrane. Predicted to be active in apical plasma membrane. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in intestinal hypomagnesemia 1 and metal metabolism disorder. Orthologous to human TRPM6 (transient receptor potential cation channel subfamily M member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 96.2), Lung (RPKM 64.4) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q51

Exon count:: 43

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (225559528..225747106)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (216136407..216320523)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (234478908..234631264, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reactive Oxygen Species Downregulate Transient Receptor Potential Melastatin 6 Expression Mediated by the Elevation of miR-24-3p in Renal Tubular Epithelial Cells.
Title: Reactive Oxygen Species Downregulate Transient Receptor Potential Melastatin 6 Expression Mediated by the Elevation of miR-24-3p in Renal Tubular Epithelial Cells.
The effects of TRPM2, TRPM6, TRPM7 and TRPM8 gene expression in hepatic ischemia reperfusion injury.
Title: The effects of TRPM2, TRPM6, TRPM7 and TRPM8 gene expression in hepatic ischemia reperfusion injury.
TNF-alpha rescues the EGFR tyrosine kinase inhibitor-induced decrease in TRPM6 expression and Mg2+ influx mediated via the activation of an NF-kappaB signaling pathway.
Title: Up-Regulation of Transient Receptor Potential Melastatin 6 Channel Expression by Tumor Necrosis Factor-α in the Presence of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor.
TRPM6, located principally in distal convoluted tubules, appears to be a susceptible molecule that causes hypermagnesiuric hypomagnesemia
Title: Downregulation of transient receptor potential M6 channels as a cause of hypermagnesiuric hypomagnesemia in obese type 2 diabetic rats.
close to normal level in kidney after 48 hours of reperfusion
Title: Expressions of TRPM6 and TRPM7 and histopathological evaluation of tissues in ischemia reperfusion performed rats.
This work confirms and extends our previous results on TRPM6 modulation by Mg(2+) availability in mammary tissues.
Title: Dietary Mg2+ regulates the epithelial Mg2+ channel TRPM6 in rat mammary tissue.
Polymerase chain reaction used to check the expression of all TRPM and TRPV channel members with specific primers.
Title: Distribution profiles of transient receptor potential melastatin-related and vanilloid-related channels in prostatic tissue in rat.
Results suggest that TRPM6 expression is up-regulated by a PI3K/Akt/mTOR pathway .
Title: Decrease in transient receptor potential melastatin 6 mRNA stability caused by rapamycin in renal tubular epithelial cells.
Up-regulation of TRPM6 transcriptional activity by AP-1 in renal epithelial cells.
Title: Up-regulation of TRPM6 transcriptional activity by AP-1 in renal epithelial cells.
In sirolimus-treated animals, AQP2 expression was reduced and expression of TRPM6 was increased.
Title: Rosiglitazone prevents sirolimus-induced hypomagnesemia, hypokalemia, and downregulation of NKCC2 protein expression.

Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables calcium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables monoatomic cation channel activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in magnesium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in magnesium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in metal ion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within metal ion transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein tetramerization	IEA Inferred from Electronic Annotation more info
involved_in response to toxic substance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transient receptor potential cation channel subfamily M member 6

XP_038957309.1

EC 2.7.11.1

XP_038957310.1

EC 2.7.11.1

XP_038957311.1

EC 2.7.11.1

XP_038957312.1

EC 2.7.11.1

XP_038957313.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001432161.1 → NP_001419090.1 transient receptor potential cation channel subfamily M member 6

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

225559528..225747106

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101382.2 → XP_038957310.1 transient receptor potential cation channel subfamily M member 6 isoform X3

Conserved Domains (3) summary

TIGR00870
Location:660 → 1220

trp; transient-receptor-potential calcium channel protein

cl28917
Location:1737 → 1975

Alpha_kinase; Alpha kinase family

pfam18139
Location:100 → 362

LSDAT_euk; SLOG in TRPM
XM_039101383.2 → XP_038957311.1 transient receptor potential cation channel subfamily M member 6 isoform X2

Conserved Domains (3) summary

TIGR00870
Location:661 → 1221

trp; transient-receptor-potential calcium channel protein

cl28917
Location:1737 → 1975

Alpha_kinase; Alpha kinase family

pfam18139
Location:101 → 363

LSDAT_euk; SLOG in TRPM
XM_039101384.2 → XP_038957312.1 transient receptor potential cation channel subfamily M member 6 isoform X4

Related

ENSRNOP00000102082.1, ENSRNOT00000135056.1

Conserved Domains (3) summary

TIGR00870
Location:648 → 1208

trp; transient-receptor-potential calcium channel protein

cl28917
Location:1725 → 1963

Alpha_kinase; Alpha kinase family

pfam18139
Location:88 → 350

LSDAT_euk; SLOG in TRPM
XM_039101381.2 → XP_038957309.1 transient receptor potential cation channel subfamily M member 6 isoform X1

UniProtKB/TrEMBL

A6I0K5, F1M7G0

Related

ENSRNOP00000017892.8, ENSRNOT00000017892.9

Conserved Domains (3) summary

TIGR00870
Location:661 → 1221

trp; transient-receptor-potential calcium channel protein

cl28917
Location:1738 → 1976

Alpha_kinase; Alpha kinase family

pfam18139
Location:101 → 363

LSDAT_euk; SLOG in TRPM
XM_039101385.2 → XP_038957313.1 transient receptor potential cation channel subfamily M member 6 isoform X5

Related

ENSRNOP00000102743.1, ENSRNOT00000132012.1

Conserved Domains (4) summary

TIGR00870
Location:661 → 1178

trp; transient-receptor-potential calcium channel protein

cl28917
Location:1695 → 1933

Alpha_kinase; Alpha kinase family

pfam16519
Location:1130 → 1184

TRPM_tetra; Tetramerisation domain of TRPM

pfam18139
Location:101 → 363

LSDAT_euk; SLOG in TRPM