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    Tm7sf2 transmembrane 7 superfamily member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293688, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Tm7sf2provided by RGD
    Official Full Name
    transmembrane 7 superfamily member 2provided by RGD
    Primary source
    RGD:1311205
    See related
    EnsemblRapid:ENSRNOG00000020989 AllianceGenome:RGD:1311205
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables delta14-sterol reductase activity. Involved in cholesterol biosynthetic process. Located in endoplasmic reticulum membrane. Orthologous to human TM7SF2 (transmembrane 7 superfamily member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 396.2), Kidney (RPKM 72.9) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tm7sf2 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (212785217..212789572, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (203355930..203360287, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (221426017..221430340, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene FAU ubiquitin like and ribosomal protein S30 fusion Neighboring gene zinc finger, HIT-type containing 2 Neighboring gene VPS51 subunit of GARP complex Neighboring gene microRNA 6315 Neighboring gene transmembrane protein 262 Neighboring gene zinc finger protein-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Tm7sf2 may participate in the healing of burn wounds. Lei N, et al. Mol Med Rep, 2016 Jul. PMID 27220550
    2. Disruption of the gene encoding 3beta-hydroxysterol Delta-reductase (Tm7sf2) in mice does not impair cholesterol biosynthesis. Bennati AM, et al. FEBS J, 2008 Oct. PMID 18785926
    3. Sterol dependent regulation of human TM7SF2 gene expression: role of the encoded 3beta-hydroxysterol Delta14-reductase in human cholesterol biosynthesis. Bennati AM, et al. Biochim Biophys Acta, 2006 Jul. PMID 16784888
    4. Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Ghai R, et al. Proc Natl Acad Sci U S A, 2013 Feb 19. PMID 23382219, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108990

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables delta14-sterol reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables delta14-sterol reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cholesterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cholesterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in organelle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    delta(14)-sterol reductase TM7SF2
    Names
    delta(14)-sterol reductase
    NP_001013089.1
    XP_038964368.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013071.1 → NP_001013089.1  delta(14)-sterol reductase TM7SF2

      See identical proteins and their annotated locations for NP_001013089.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091237
      UniProtKB/TrEMBL
      A0A8I5ZP05, A6HZC6, F7FG10, Q5BK21
      Related
      ENSRNOP00000028485.3, ENSRNOT00000028485.8
      Conserved Domains (1) summary
      cl21511
      Location:8 → 418
      PEMT; Phospholipid methyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      212785217..212789572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108440.2 → XP_038964368.1  delta(14)-sterol reductase TM7SF2 isoform X1

      Conserved Domains (1) summary
      cl21511
      Location:1 → 290
      PEMT; Phospholipid methyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version

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