Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gdpd3provided by RGD
Official Full Name: glycerophosphodiester phosphodiesterase domain containing 3provided by RGD
Primary source: RGD:1308386
See related: EnsemblRapid:ENSRNOG00000019685 AllianceGenome:RGD:1308386
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1308386
Summary: Predicted to enable lysophospholipase activity and phosphoric diester hydrolase activity. Predicted to be involved in N-acylethanolamine metabolic process and phosphatidylcholine catabolic process. Predicted to be located in endoplasmic reticulum and perinuclear region of cytoplasm. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human GDPD3 (glycerophosphodiester phosphodiesterase domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 8.6), Thymus (RPKM 2.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q36

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (190804053..190813609)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (181373505..181383063)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (198199032..198209178)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Prkm3-rs1 (e-PCR), detects polymorphism
- UniSTS:144262

BI278071 (e-PCR)
- UniSTS:244204

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables lysophospholipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysophospholipase activity	ISO Inferred from Sequence Orthology more info
enables phosphoric diester hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoric diester hydrolase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in N-acylethanolamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycerophospholipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylcholine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipid metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lysophospholipase D GDPD3

Names: glycerophosphodiester phosphodiesterase domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001305187.1 → NP_001292116.1 lysophospholipase D GDPD3

See identical proteins and their annotated locations for NP_001292116.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6I9C2, A6I9C8, D4A1N8

Related

ENSRNOP00000107971.1, ENSRNOT00000152860.1

Conserved Domains (2) summary

cd08612
Location:13 → 310

GDPD_GDE4; Glycerophosphodiester phosphodiesterase domain of mammalian glycerophosphodiester phosphodiesterase GDE4 and similar proteins

COG0584
Location:39 → 311

UgpQ; Glycerophosphoryl diester phosphodiesterase [Lipid transport and metabolism]