Lyve1 lymphatic vessel endothelial hyaluronan receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lyve1provided by RGD
Official Full Name: lymphatic vessel endothelial hyaluronan receptor 1provided by RGD
Primary source: RGD:1310864
See related: EnsemblRapid:ENSRNOG00000087179 AllianceGenome:RGD:1310864
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Xlkd1
Summary: Predicted to enable cargo receptor activity; hyaluronic acid binding activity; and transmembrane signaling receptor activity. Predicted to be involved in hyaluronan catabolic process; positive regulation of cellular extravasation; and receptor-mediated endocytosis. Predicted to act upstream of or within glycosaminoglycan catabolic process. Predicted to be located in cell periphery. Predicted to be active in plasma membrane. Orthologous to human LYVE1 (lymphatic vessel endothelial hyaluronan receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 301.8), Liver (RPKM 150.0) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q33

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (174393387..174410977, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (164962872..164976309, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (175663266..175676699, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of Lyve1 followed the same temporal pattern as hyaluronic acid deposition in a bladder regeneration model.
Title: Temporal expression of hyaluronic acid and hyaluronic acid receptors in a porcine small intestinal submucosa-augmented rat bladder regeneration model.
Different levels of protein for LYVE-1-positive cells may reflect alterations in the functional properties of the blood supply.
Title: Distribution of LYVE-1 and CD31 in postnatal rat masseter muscle.
Upregulation of hyaluronan and its binding receptors CD44 and LYVE-1 are involved in interstitial fibrosis in chronic cyclosporine-induced renal injury.
Title: Upregulation of hyaluronan and its binding receptors in an experimental model of chronic cyclosporine nephropathy.
Immunostaining for the specific lymphatic markers LYVE-1 revealed an extensive lymphatic vessel system in dental tissues. Unexpected cell staining for the above lymphatic markers was found in the pulp of both molars and incisors in rats.
Title: Characterization of the dental lymphatic system and identification of cells immunopositive to specific lymphatic markers.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cargo receptor activity	ISO Inferred from Sequence Orthology more info
enables hyaluronic acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables hyaluronic acid binding	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within glycosaminoglycan catabolic process	ISO Inferred from Sequence Orthology more info
involved_in hyaluronan catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cellular extravasation	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell periphery	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lymphatic vessel endothelial hyaluronic acid receptor 1

Names: extra cellular link domain-containing 1; extracellular link domain-containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106286.1 → NP_001099756.1 lymphatic vessel endothelial hyaluronic acid receptor 1

See identical proteins and their annotated locations for NP_001099756.1

Status: PROVISIONAL

Source sequence(s)

CH473956

UniProtKB/TrEMBL

A6I828

Related

ENSRNOP00000101959.1, ENSRNOT00000121668.1

Conserved Domains (1) summary

cd03516
Location:62 → 186

Link_domain_CD44_like; This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

174393387..174410977 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063285308.1 → XP_063141378.1 lymphatic vessel endothelial hyaluronic acid receptor 1 isoform X1
XM_063285311.1 → XP_063141381.1 lymphatic vessel endothelial hyaluronic acid receptor 1 isoform X2

Related

ENSRNOP00000108493.1, ENSRNOT00000172888.1