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    Epha6 Eph receptor A6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29202, updated on 10-Oct-2024

    Summary

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    Symbol
    Epha6provided by RGD
    Full Name
    Eph receptor A6provided by RGD
    Primary source
    RGD:1304614
    See related
    EnsemblRapid:ENSRNOG00000029184 AllianceGenome:RGD:1304614
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ehk2; EHK-2; AABR07033882.1
    Summary
    Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axon guidance; positive regulation of kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be located in nucleoplasm. Predicted to be part of receptor complex. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Orthologous to human EPHA6 (EPH receptor A6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 62.8) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Epha6 in Genome Data Viewer
    Location:
    11q12
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (53226784..54178120)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (39757501..40708901)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (41867607..42843800)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene vesicle trafficking 1, pseudogene 1 Neighboring gene uncharacterized LOC120095545 Neighboring gene acetyl-CoA acetyltransferase 2, pseudogene 1 Neighboring gene uncharacterized LOC134480984 Neighboring gene U7 small nuclear RNA Neighboring gene ADP-ribosylation factor like GTPase 6 Neighboring gene crystallin beta-gamma domain containing 3 Neighboring gene ribosomal oxygenase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ehk-1 and Ehk-2: two novel members of the Eph receptor-like tyrosine kinase family with distinctive structures and neuronal expression. Maisonpierre PC, et al. Oncogene, 1993 Dec. PMID 7504232
    2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane-ephrin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ephrin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ephrin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ephrin type-A receptor 6
    Names
    EPH homology kinase 2
    tyrosine-protein kinase receptor EHK-2
    NP_001406458.1
    XP_038944648.1
    XP_038944649.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419529.1 → NP_001406458.1  ephrin type-A receptor 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A8I6A6J8
      Related
      ENSRNOP00000087819.1, ENSRNOT00000097751.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      53226784..54178120
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088720.2 → XP_038944648.1  ephrin type-A receptor 6 isoform X1

      UniProtKB/Swiss-Prot
      P54758
      Conserved Domains (7) summary
      cd09547
      Location:918 → 981
      SAM_EPH-A6; SAM domain of EPH-A6 subfamily of tyrosine kinase receptors
      cd00063
      Location:412 → 491
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:583 → 891
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam00041
      Location:290 → 384
      fn3; Fibronectin type III domain
      pfam07699
      Location:231 → 269
      Ephrin_rec_like; Putative ephrin-receptor like
      pfam14575
      Location:507 → 585
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl02704
      Location:1 → 163
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors

    2. XM_039088721.2 → XP_038944649.1  ephrin type-A receptor 6 isoform X2

      UniProtKB/Swiss-Prot
      P54758
      UniProtKB/TrEMBL
      F1LQK6
      Related
      ENSRNOP00000049409.6, ENSRNOT00000047310.7
      Conserved Domains (7) summary
      cd09547
      Location:899 → 962
      SAM_EPH-A6; SAM domain of EPH-A6 subfamily of tyrosine kinase receptors
      cd00063
      Location:393 → 472
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:564 → 872
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam00041
      Location:271 → 365
      fn3; Fibronectin type III domain
      pfam07699
      Location:212 → 250
      Ephrin_rec_like; Putative ephrin-receptor like
      pfam14575
      Location:488 → 566
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl02704
      Location:1 → 144
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54758.2 GenPept UniProtKB/Swiss-Prot:P54758

    Gene LinkOut

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    Chemical Information
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