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    Katnb1 katanin regulatory subunit B1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291852, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Katnb1provided by RGD
    Official Full Name
    katanin regulatory subunit B1provided by RGD
    Primary source
    RGD:1311256
    See related
    EnsemblRapid:ENSRNOG00000014626 AllianceGenome:RGD:1311256
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATPase regulator activity; dynein complex binding activity; and protein heterodimerization activity. Involved in microtubule severing; positive regulation of apoptotic process; and positive regulation of neuron projection development. Located in growth cone; midbody; and neuronal cell body. Human ortholog(s) of this gene implicated in lissencephaly 6. Orthologous to human KATNB1 (katanin regulatory subunit B1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Testes (RPKM 230.2), Brain (RPKM 84.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Katnb1 in Genome Data Viewer
    Location:
    19p13
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (9927249..9946750, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (9921216..9940853, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (10340027..10360319, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene cyclic nucleotide gated channel subunit beta 1 Neighboring gene U2 spliceosomal RNA Neighboring gene kinesin family member C3 Neighboring gene uncharacterized LOC134483686 Neighboring gene dynein regulatory complex subunit 7 Neighboring gene adhesion G protein-coupled receptor G3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. LAPSER1 is a putative cytokinetic tumor suppressor that shows the same centrosome and midbody subcellular localization pattern as p80 katanin. Sudo H, et al. FASEB J, 2007 Jul. PMID 17351128
    2. Regulation of microtubule severing by katanin subunits during neuronal development. Yu W, et al. J Neurosci, 2005 Jun 8. PMID 15944385, Free PMC Article
    3. Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin. McNally KP, et al. J Cell Sci, 2000 May. PMID 10751153
    4. Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit. Hartman JJ, et al. Cell, 1998 Apr 17. PMID 9568719
    5. Proteomic Analysis of the Mammalian Katanin Family of Microtubule-severing Enzymes Defines Katanin p80 subunit B-like 1 (KATNBL1) as a Regulator of Mammalian Katanin Microtubule-severing. Cheung K, et al. Mol Cell Proteomics, 2016 May. PMID 26929214, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dynein complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule severing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic chromosome movement towards spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of katanin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of katanin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    katanin p80 WD40 repeat-containing subunit B1
    Names
    katanin p80 (WD repeat containing) subunit B 1
    katanin p80 (WD40-containing) subunit B 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024746.2 → NP_001019917.1  katanin p80 WD40 repeat-containing subunit B1

      See identical proteins and their annotated locations for NP_001019917.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      B1WBN6, Q4VFZ4
      Conserved Domains (4) summary
      PRK14951
      Location:386 → 494
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
      cd00200
      Location:7 → 257
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:67 → 103
      7WD40; WD40 repeat [structural motif]
      pfam13925
      Location:497 → 648
      Katanin_con80; con80 domain of Katanin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      9927249..9946750 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277855.1 → XP_063133925.1  katanin p80 WD40 repeat-containing subunit B1 isoform X4

    2. XM_017601201.3 → XP_017456690.1  katanin p80 WD40 repeat-containing subunit B1 isoform X2

      UniProtKB/TrEMBL
      B1WBN6
      Conserved Domains (3) summary
      cd00200
      Location:7 → 257
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:67 → 103
      7WD40; WD40 repeat [structural motif]
      pfam13925
      Location:496 → 651
      Katanin_con80; con80 domain of Katanin

    3. XM_017601198.3 → XP_017456687.1  katanin p80 WD40 repeat-containing subunit B1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JX20, B1WBN6
      Related
      ENSRNOP00000070102.2, ENSRNOT00000087100.3
      Conserved Domains (4) summary
      PRK14951
      Location:386 → 494
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
      cd00200
      Location:7 → 257
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:67 → 103
      7WD40; WD40 repeat [structural motif]
      pfam13925
      Location:497 → 652
      Katanin_con80; con80 domain of Katanin

    4. XM_063277854.1 → XP_063133924.1  katanin p80 WD40 repeat-containing subunit B1 isoform X3

      UniProtKB/TrEMBL
      Q4VFZ4

    5. XM_063277852.1 → XP_063133922.1  katanin p80 WD40 repeat-containing subunit B1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JX20

    6. XM_063277856.1 → XP_063133926.1  katanin p80 WD40 repeat-containing subunit B1 isoform X4

    7. XM_063277853.1 → XP_063133923.1  katanin p80 WD40 repeat-containing subunit B1 isoform X3

      UniProtKB/TrEMBL
      Q4VFZ4

    8. XM_017601200.3 → XP_017456689.1  katanin p80 WD40 repeat-containing subunit B1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JX20, B1WBN6
      Conserved Domains (4) summary
      PRK14951
      Location:386 → 494
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
      cd00200
      Location:7 → 257
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:67 → 103
      7WD40; WD40 repeat [structural motif]
      pfam13925
      Location:497 → 652
      Katanin_con80; con80 domain of Katanin
    Nucleotide Protein Strain
    Heading Accession and Version

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