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    Usp14 ubiquitin specific peptidase 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291796, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Usp14provided by RGD
    Official Full Name
    ubiquitin specific peptidase 14provided by RGD
    Primary source
    RGD:1311825
    See related
    EnsemblRapid:ENSRNOG00000014981 AllianceGenome:RGD:1311825
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable endopeptidase inhibitor activity; proteasome binding activity; and thiol-dependent deubiquitinase. Predicted to be involved in negative regulation of ER-associated ubiquitin-dependent protein catabolic process; protein deubiquitination; and regulation of chemotaxis. Predicted to act upstream of or within chemical synaptic transmission. Predicted to be located in several cellular components, including cell surface; cytoplasmic vesicle; and cytosol. Predicted to be part of proteasome complex. Orthologous to human USP14 (ubiquitin specific peptidase 14). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 487.9), Heart (RPKM 287.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    18p13
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (1292745..1330867, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (1018111..1057727, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (1178785..1216573, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene SEC13 homolog, nuclear pore and COPII coat complex component, pseudogene 2 Neighboring gene uncharacterized LOC134482897 Neighboring gene THO complex subunit 1 Neighboring gene NDUFA4, mitochondrial complex associated, pseudogene 2 Neighboring gene Rho-associated coiled-coil containing protein kinase 1 Neighboring gene DNA-directed RNA polymerases I, II, and III subunit RPABC3-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ubiquitin-specific protease 14 regulates cardiac hypertrophy progression by increasing GSK-3β phosphorylation. Liu N, et al. Biochem Biophys Res Commun, 2016 Sep 23. PMID 27545607
    2. Inhibition of deubiquitinating activity of USP14 decreases tyrosine hydroxylase phosphorylated at Ser19 in PC12D cells. Nakashima A, et al. Biochem Biophys Res Commun, 2016 Apr 15. PMID 26969276
    3. Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling. Jung H, et al. Oncogenesis, 2013 Aug 19. PMID 23958854, Free PMC Article
    4. Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's disease. Kiprowska MJ, et al. Biochim Biophys Acta Mol Basis Dis, 2017 Jun. PMID 28372990, Free PMC Article
    5. Post-endocytotic Deubiquitination and Degradation of the Metabotropic γ-Aminobutyric Acid Receptor by the Ubiquitin-specific Protease 14. Lahaie N, et al. J Biol Chem, 2016 Mar 25. PMID 26817839, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. pharmacologically inhibiting (with low or high IU1 concentrations) or genetically down-regulating USP14 fail to enhance proteasomal degradation of Ub-proteins or Tau in neurons.
      Title: Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's disease.
    2. mediates the development of cardiac hypertrophy by promoting GSK-3beta phosphorylation.
      Title: Ubiquitin-specific protease 14 regulates cardiac hypertrophy progression by increasing GSK-3β phosphorylation.
    3. Activation of proteasome degradation by IU-1, which is an inhibitor for the deubiquitinating activity of USP14, decreased only the quantity of TH molecules phosphorylated at their Ser19.
      Title: Inhibition of deubiquitinating activity of USP14 decreases tyrosine hydroxylase phosphorylated at Ser19 in PC12D cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC95160

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables K63-linked deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proteasome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proteasome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of proteasomal protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 14
    Names
    ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
    ubiquitin specific protease 14
    NP_001008302.1
    XP_006254458.1
    XP_006254460.1
    XP_063133342.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008301.2 → NP_001008302.1  ubiquitin carboxyl-terminal hydrolase 14

      See identical proteins and their annotated locations for NP_001008302.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A8I5ZY29, Q5U2N2
      Related
      ENSRNOP00000020537.7, ENSRNOT00000020537.8
      Conserved Domains (2) summary
      cd02657
      Location:106 → 480
      Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
      cd16104
      Location:4 → 76
      Ubl_USP14_like; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 14 (USP14) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      1292745..1330867 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254396.4 → XP_006254458.1  ubiquitin carboxyl-terminal hydrolase 14 isoform X1

      See identical proteins and their annotated locations for XP_006254458.1

      UniProtKB/TrEMBL
      A0A8I5ZY29, Q5U2N2
      Conserved Domains (2) summary
      cd02657
      Location:106 → 480
      Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
      cd16104
      Location:4 → 76
      Ubl_USP14_like; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 14 (USP14) and similar proteins

    2. XM_006254398.5 → XP_006254460.1  ubiquitin carboxyl-terminal hydrolase 14 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZR30
      Related
      ENSRNOP00000069634.3, ENSRNOT00000084613.3
      Conserved Domains (2) summary
      cd02657
      Location:71 → 445
      Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
      cd16104
      Location:4 → 65
      Ubl_USP14_like; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 14 (USP14) and similar proteins

    3. XM_063277272.1 → XP_063133342.1  ubiquitin carboxyl-terminal hydrolase 14 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZR30
    Nucleotide Protein Strain
    Heading Accession and Version

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