Dctn1 dynactin subunit 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dctn1provided by RGD
Official Full Name: dynactin subunit 1provided by RGD
Primary source: RGD:62038
See related: EnsemblRapid:ENSRNOG00000010048 AllianceGenome:RGD:62038
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables identical protein binding activity and microtubule binding activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; plasma membrane bounded cell projection organization; and regulation of microtubule cytoskeleton organization. Predicted to act upstream of or within melanosome transport. Part of cytoplasmic dynein complex. Biomarker of synucleinopathy. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and distal hereditary motor neuronopathy type 7B. Orthologous to human DCTN1 (dynactin subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 396.1), Heart (RPKM 195.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (117228722..117261528)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (115671024..115703824)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (114876770..114896567)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Conformational Flexibility of p150(Glued)(1-191) Subunit of Dynactin Assembled with Microtubules.
Title: Conformational Flexibility of p150(Glued)(1-191) Subunit of Dynactin Assembled with Microtubules.
Data show that axonal synthesis of Lis1 and p150Glued is required for the adjustment of retrograde transport to acutely changing neurotrophin signalling in the periphery of neurons.
Title: Local synthesis of dynein cofactors matches retrograde transport to acutely changing demands.
overexpression of p150Glued, a major component of the dynactin complex, and microtubule stabilization cooperatively suppress axon degeneration.
Title: Cooperative effect of p150Glued and microtubule stabilization to suppress excitotoxicity-induced axon degeneration.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_6321-6322:992007238:1 (e-PCR)
- UniSTS:231230

MARC_6321-6322:997299551:1 (e-PCR)
- UniSTS:231230

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	EXP Inferred from Experiment more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables tubulin binding	ISO Inferred from Sequence Orthology more info
enables tubulin binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
NOT involved_in axonal transport	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in centriole-centriole cohesion	IEA Inferred from Electronic Annotation more info
involved_in centriole-centriole cohesion	ISO Inferred from Sequence Orthology more info
involved_in centriole-centriole cohesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytoplasmic microtubule organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of mitotic spindle orientation	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of mitotic spindle orientation	IEA Inferred from Electronic Annotation more info
involved_in establishment of mitotic spindle orientation	ISO Inferred from Sequence Orthology more info
involved_in establishment of mitotic spindle orientation	ISS Inferred from Sequence or Structural Similarity more info
involved_in melanosome transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within melanosome transport	ISO Inferred from Sequence Orthology more info
involved_in microtubule anchoring at centrosome	IEA Inferred from Electronic Annotation more info
involved_in microtubule anchoring at centrosome	ISO Inferred from Sequence Orthology more info
involved_in microtubule anchoring at centrosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in motor behavior	IEA Inferred from Electronic Annotation more info
involved_in motor behavior	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular junction development	IEA Inferred from Electronic Annotation more info
involved_in neuromuscular junction development	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular process	IEA Inferred from Electronic Annotation more info
involved_in neuromuscular process	ISO Inferred from Sequence Orthology more info
involved_in neuron cellular homeostasis	IEA Inferred from Electronic Annotation more info
involved_in neuron cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in neuron projection maintenance	IEA Inferred from Electronic Annotation more info
involved_in neuron projection maintenance	ISO Inferred from Sequence Orthology more info
involved_in non-motile cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in non-motile cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in non-motile cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in nuclear membrane disassembly	IEA Inferred from Electronic Annotation more info
involved_in nuclear membrane disassembly	ISO Inferred from Sequence Orthology more info
involved_in nuclear membrane disassembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in nuclear migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of intracellular protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of microtubule nucleation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of microtubule nucleation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of microtubule nucleation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of microtubule polymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuromuscular junction development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuromuscular junction development	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic spindle organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitotic spindle organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic spindle organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in retrograde transport, endosome to Golgi	IEA Inferred from Electronic Annotation more info
involved_in retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info
involved_in ventral spinal cord development	IEA Inferred from Electronic Annotation more info
involved_in ventral spinal cord development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell cortex	ISS Inferred from Sequence or Structural Similarity more info
located_in cell leading edge	IEA Inferred from Electronic Annotation more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
part_of centriolar subdistal appendage	IEA Inferred from Electronic Annotation more info
part_of centriolar subdistal appendage	ISO Inferred from Sequence Orthology more info
located_in centriole	IEA Inferred from Electronic Annotation more info
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in centriole	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in ciliary basal body	IEA Inferred from Electronic Annotation more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of cytoplasmic dynein complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
part_of dynein complex	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISS Inferred from Sequence or Structural Similarity more info
part_of microtubule associated complex	IBA Inferred from Biological aspect of Ancestor more info
part_of microtubule associated complex	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in microtubule plus-end	IEA Inferred from Electronic Annotation more info
located_in microtubule plus-end	ISO Inferred from Sequence Orthology more info
located_in microtubule plus-end	ISS Inferred from Sequence or Structural Similarity more info
located_in mitotic spindle	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of retromer complex	IEA Inferred from Electronic Annotation more info
part_of retromer complex	ISO Inferred from Sequence Orthology more info
located_in spindle	ISO Inferred from Sequence Orthology more info
located_in spindle	ISS Inferred from Sequence or Structural Similarity more info
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dynactin subunit 1

Names: 150 kDa dynein-associated polypeptide; DAP-150; DP-150; dynactin 1; p150-glued

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024130.2 → NP_077044.2 dynactin subunit 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

P28023

UniProtKB/TrEMBL

A0A0G2K428, A6IAL4

Related

ENSRNOP00000080377.2, ENSRNOT00000110975.2

Conserved Domains (5) summary

TIGR02168
Location:220 → 540

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

TIGR02169
Location:924 → 1037

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam05109
Location:101 → 214

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01302
Location:29 → 94

CAP_GLY; CAP-Gly domain

pfam12455
Location:527 → 805

Dynactin; Dynein associated protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

117228722..117261528

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107183.2 → XP_038963111.1 dynactin subunit 1 isoform X6

UniProtKB/TrEMBL

A0A8I5ZPT7

Related

ENSRNOP00000095934.2, ENSRNOT00000100284.2

Conserved Domains (5) summary

TIGR02168
Location:203 → 523

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

TIGR02169
Location:907 → 1020

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam05109
Location:84 → 197

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01302
Location:12 → 77

CAP_GLY; CAP-Gly domain

pfam12455
Location:510 → 788

Dynactin; Dynein associated protein
XM_039107184.2 → XP_038963112.1 dynactin subunit 1 isoform X6

UniProtKB/TrEMBL

A0A8I5ZPT7

Conserved Domains (5) summary

TIGR02168
Location:203 → 523

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

TIGR02169
Location:907 → 1020

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam05109
Location:84 → 197

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01302
Location:12 → 77

CAP_GLY; CAP-Gly domain

pfam12455
Location:510 → 788

Dynactin; Dynein associated protein
XM_063285669.1 → XP_063141739.1 dynactin subunit 1 isoform X9

UniProtKB/TrEMBL

A0A8I6ASG8
XM_039107185.2 → XP_038963113.1 dynactin subunit 1 isoform X10

UniProtKB/TrEMBL

A0A8I6A3U0

Related

ENSRNOP00000082429.1, ENSRNOT00000107740.2

Conserved Domains (4) summary

TIGR02168
Location:200 → 520

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

TIGR02169
Location:904 → 1017

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam01302
Location:29 → 94

CAP_GLY; CAP-Gly domain

pfam12455
Location:507 → 785

Dynactin; Dynein associated protein
XM_063285663.1 → XP_063141733.1 dynactin subunit 1 isoform X1

UniProtKB/Swiss-Prot

P28023

UniProtKB/TrEMBL

A0A8I6A3U0, A6IAL5
XM_063285664.1 → XP_063141734.1 dynactin subunit 1 isoform X2

UniProtKB/TrEMBL

A0A8I6ASG8

Related

ENSRNOP00000072880.3, ENSRNOT00000078175.3
XM_063285666.1 → XP_063141736.1 dynactin subunit 1 isoform X5

UniProtKB/TrEMBL

A0A8I6ASG8
XM_063285668.1 → XP_063141738.1 dynactin subunit 1 isoform X8

UniProtKB/TrEMBL

A0A8I6A3U0
XM_039107182.2 → XP_038963110.1 dynactin subunit 1 isoform X3

UniProtKB/TrEMBL

A0A8I6ASG8

Conserved Domains (5) summary

TIGR02168
Location:213 → 533

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

TIGR02169
Location:917 → 1030

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam05109
Location:101 → 207

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01302
Location:29 → 94

CAP_GLY; CAP-Gly domain

pfam12455
Location:520 → 798

Dynactin; Dynein associated protein
XM_063285665.1 → XP_063141735.1 dynactin subunit 1 isoform X4

UniProtKB/TrEMBL

A0A8I6ASG8
XM_063285667.1 → XP_063141737.1 dynactin subunit 1 isoform X7

UniProtKB/TrEMBL

A0A8I6A3U0, D4A8U7, G3V7A8

Related

ENSRNOP00000059076.3, ENSRNOT00000068102.5