Ftmt ferritin mitochondrial [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ftmtprovided by RGD
Official Full Name: ferritin mitochondrialprovided by RGD
Primary source: RGD:1306563
See related: EnsemblRapid:ENSRNOG00000014988 AllianceGenome:RGD:1306563
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ferric iron binding activity and ferrous iron binding activity. Predicted to be involved in several processes, including intracellular sequestering of iron ion; positive regulation of aconitate hydratase activity; and positive regulation of succinate dehydrogenase activity. Predicted to be active in cytoplasm. Orthologous to human FTMT (ferritin mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: 18q11

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (47957235..47958484)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (45758874..45760123)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (47294292..47295541)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mitochondrial Ferritin Deficiency Promotes Osteoblastic Ferroptosis Via Mitophagy in Type 2 Diabetic Osteoporosis.
Title: Mitochondrial Ferritin Deficiency Promotes Osteoblastic Ferroptosis Via Mitophagy in Type 2 Diabetic Osteoporosis.
Ferritin contributes to apoptosis in primary epatocytes in an autocrine, density dependent mode, involving Fas stimulation and proapoptotic mitochondrial signalling.
Title: Ferritin and FasL (CD95L) mediate density dependent apoptosis in primary rat hepatocytes.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ferric iron binding	IBA Inferred from Biological aspect of Ancestor more info
enables ferrous iron binding	IBA Inferred from Biological aspect of Ancestor more info
enables ferroxidase activity	ISO Inferred from Sequence Orthology more info
enables iron ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in intracellular iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in iron ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of aconitate hydratase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of aconitate hydratase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lyase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of succinate dehydrogenase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of succinate dehydrogenase activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ferritin, mitochondrial

NP_001099606.1

EC 1.16.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.