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    Hecw1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291209, updated on 2-Nov-2024

    Summary

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    Symbol
    Hecw1provided by RGD
    Full Name
    HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1provided by RGD
    Primary source
    RGD:1561038
    See related
    EnsemblRapid:ENSRNOG00000016046 AllianceGenome:RGD:1561038
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561038
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in regulation of dendrite morphogenesis and ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm. Orthologous to human HECW1 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 147.4), Testes (RPKM 14.8) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hecw1 in Genome Data Viewer
    Location:
    17q12.1
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (55366904..55780028)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (50671239..51084536)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (53229997..53777474)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene proteasome 20S subunit alpha 2 Neighboring gene mitochondrial ribosomal protein L32 Neighboring gene RB binding protein 4, chromatin remodeling factor, pseudogene 2 Neighboring gene 40S ribosomal protein S19 pseudogene Neighboring gene Y-box-binding protein 1-like Neighboring gene AT-rich interaction domain 4B Neighboring gene geranylgeranyl diphosphate synthase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Circular RNA Hecw1 Regulates the Inflammatory Imbalance in Spinal Cord Injury via miR-3551-3p/LRRTM1 Axis. Ban D, et al. Appl Biochem Biotechnol, 2022 Nov. PMID 35699802
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circular RNA Hecw1 Regulates the Inflammatory Imbalance in Spinal Cord Injury via miR-3551-3p/LRRTM1 Axis.
      Title: Circular RNA Hecw1 Regulates the Inflammatory Imbalance in Spinal Cord Injury via miR-3551-3p/LRRTM1 Axis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of dendrite morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase HECW1
    Names
    E3 ubiquitin-protein ligase HECW1-like
    NP_001099587.1
    XP_008769919.1
    XP_017455974.1
    XP_017455975.1
    XP_017455976.1
    XP_017455977.1
    XP_017455978.1
    XP_017455979.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106117.1 → NP_001099587.1  E3 ubiquitin-protein ligase HECW1

      See identical proteins and their annotated locations for NP_001099587.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474030
      UniProtKB/TrEMBL
      A0A8I6A475, A6K9C5, F1M4Q8
      Related
      ENSRNOP00000021703.5, ENSRNOT00000021703.7
      Conserved Domains (5) summary
      cd08691
      Location:197 → 333
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:818 → 848
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:1262 → 1591
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1238 → 1592
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam16562
      Location:57 → 176
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      55366904..55780028
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017600485.3 → XP_017455974.1  E3 ubiquitin-protein ligase HECW1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A475, A0A8I6AG92, A6K9C4
      Conserved Domains (5) summary
      cd08691
      Location:206 → 342
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:827 → 857
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:1271 → 1600
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1247 → 1601
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam16562
      Location:66 → 185
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

    2. XM_017600489.3 → XP_017455978.1  E3 ubiquitin-protein ligase HECW1 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A475

    3. XM_017600487.3 → XP_017455976.1  E3 ubiquitin-protein ligase HECW1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A475
      Related
      ENSRNOP00000091762.2, ENSRNOT00000114793.2

    4. XM_017600490.3 → XP_017455979.1  E3 ubiquitin-protein ligase HECW1 isoform X6

      UniProtKB/TrEMBL
      A0A8I6A475

    5. XM_008771697.4 → XP_008769919.1  E3 ubiquitin-protein ligase HECW1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZQP0, A0A8I6A475
      Related
      ENSRNOP00000080972.1, ENSRNOT00000100241.2
      Conserved Domains (5) summary
      cd08691
      Location:205 → 341
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:826 → 856
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:1270 → 1599
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1246 → 1600
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam16562
      Location:65 → 184
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

    6. XM_017600486.3 → XP_017455975.1  E3 ubiquitin-protein ligase HECW1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZQP0, A0A8I6A475
      Conserved Domains (5) summary
      cd08691
      Location:205 → 341
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:826 → 856
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:1270 → 1599
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1246 → 1600
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam16562
      Location:65 → 184
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

    7. XM_017600488.3 → XP_017455977.1  E3 ubiquitin-protein ligase HECW1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A475, A6K9C6
      Conserved Domains (6) summary
      cd08691
      Location:184 → 320
      C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
      smart00456
      Location:995 → 1026
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:1249 → 1578
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1225 → 1579
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:806 → 835
      WW; WW domain
      pfam16562
      Location:44 → 163
      HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
    Nucleotide Protein Strain
    Heading Accession and Version

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