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    Erlec1 endoplasmic reticulum lectin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289874, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Erlec1provided by RGD
    Official Full Name
    endoplasmic reticulum lectin 1provided by RGD
    Primary source
    RGD:1306508
    See related
    EnsemblRapid:ENSRNOG00000007283 AllianceGenome:RGD:1306508
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306508
    Summary
    Predicted to enable unfolded protein binding activity. Predicted to be involved in negative regulation of retrograde protein transport, ER to cytosol and ubiquitin-dependent ERAD pathway. Predicted to be located in endoplasmic reticulum lumen. Orthologous to human ERLEC1 (endoplasmic reticulum lectin 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 301.5), Kidney (RPKM 291.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Erlec1 in Genome Data Viewer
    Location:
    14q22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (108856661..108894511, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (104655745..104693508, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (115314890..115352871, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene proteasome activator subunit 4 Neighboring gene G protein-coupled receptor 75 Neighboring gene ankyrin repeat and SOCS box-containing 3 Neighboring gene ChaC glutathione specific gamma-glutamylcyclotransferase 2 Neighboring gene uncharacterized LOC134481883

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The MRH protein Erlectin is a member of the endoplasmic reticulum synexpression group and functions in N-glycan recognition. Cruciat CM, et al. J Biol Chem, 2006 May 5. PMID 16531414
    2. Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP. Hosokawa N, et al. J Biol Chem, 2008 Jul 25. PMID 18502753, Free PMC Article
    3. OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. Christianson JC, et al. Nat Cell Biol, 2008 Mar. PMID 18264092, Free PMC Article
    4. Mannose trimming is required for delivery of a glycoprotein from EDEM1 to XTP3-B and to late endoplasmic reticulum-associated degradation steps. Groisman B, et al. J Biol Chem, 2011 Jan 14. PMID 21062743, Free PMC Article
    5. Identification of ERAD components essential for dislocation of the null Hong Kong variant of α-1-antitrypsin (NHK). Zhong Y, et al. Biochem Biophys Res Commun, 2015 Mar 6. PMID 25660456

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum unfolded protein response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde protein transport, ER to cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    endoplasmic reticulum lectin 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106023.1 → NP_001099493.2  endoplasmic reticulum lectin 1 precursor

      See identical proteins and their annotated locations for NP_001099493.2

      Status: PROVISIONAL

      Source sequence(s)
      CH473996
      UniProtKB/TrEMBL
      A6JQD3, D3ZF97
      Related
      ENSRNOP00000043115.4, ENSRNOT00000050321.6
      Conserved Domains (2) summary
      pfam07915
      Location:341 → 420
      PRKCSH; Glucosidase II beta subunit-like protein
      cl06793
      Location:205 → 249
      PRKCSH; Glucosidase II beta subunit-like protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      108856661..108894511 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091779.2 → XP_038947707.1  endoplasmic reticulum lectin 1 isoform X2

      Conserved Domains (1) summary
      pfam07915
      Location:223 → 302
      PRKCSH; Glucosidase II beta subunit-like protein

    2. XM_063272989.1 → XP_063129059.1  endoplasmic reticulum lectin 1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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