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    Fignl1 fidgetin-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289777, updated on 13-Jul-2024

    Summary

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    Official Symbol
    Fignl1provided by RGD
    Official Full Name
    fidgetin-like 1provided by RGD
    Primary source
    RGD:1307112
    See related
    EnsemblRapid:ENSRNOG00000004440 AllianceGenome:RGD:1307112
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable hydrolase activity; magnesium ion binding activity; and microtubule-severing ATPase activity. Predicted to be involved in several processes, including cellular response to ionizing radiation; osteoblast proliferation; and regulation of double-strand break repair via homologous recombination. Predicted to act upstream of or within negative regulation of intrinsic apoptotic signaling pathway. Predicted to be located in nuclear chromosome and perinuclear region of cytoplasm. Orthologous to human FIGNL1 (fidgetin like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 39.2), Thymus (RPKM 30.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fignl1 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (90573090..90595342, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (86368670..86381728, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (91895902..91904474, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene phosphoglucomutase 1, pseudogene 1 Neighboring gene IKAROS family zinc finger 1 Neighboring gene uncharacterized LOC120096666 Neighboring gene uncharacterized LOC120096667 Neighboring gene dopa decarboxylase Neighboring gene growth factor receptor bound protein 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. mRNA expression analysis of cell cycle genes in islets of pregnant mice. Schraenen A, et al. Diabetologia, 2010 Dec. PMID 20886204, Free PMC Article
    2. Fidgetin-like 1 gene inhibited by basic fibroblast growth factor regulates the proliferation and differentiation of osteoblasts. Park SJ, et al. J Bone Miner Res, 2007 Jun. PMID 17352653
    3. Fidgetin-like1 is a strong candidate for a dynamic impairment of male meiosis leading to reduced testis weight in mice. L'Hôte D, et al. PLoS One, 2011. PMID 22110678, Free PMC Article
    4. Identification of novel E2F1 target genes regulated in cell cycle-dependent and independent manners. Iwanaga R, et al. Oncogene, 2006 Mar 16. PMID 16288221
    5. FIGNL1-containing protein complex is required for efficient homologous recombination repair. Yuan J, et al. Proc Natl Acad Sci U S A, 2013 Jun 25. PMID 23754376, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables microtubule severing ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to ionizing radiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in male meiotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in male meiotic nuclear division ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in osteoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in osteoblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in osteoblast proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of double-strand break repair via homologous recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear chromosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    fidgetin-like protein 1
    NP_001011913.1
    NP_001380737.1
    NP_001380738.1
    XP_006251539.1
    XP_063129023.1
    XP_063129024.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011913.2 → NP_001011913.1  fidgetin-like protein 1

      See identical proteins and their annotated locations for NP_001011913.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      Q6GX84
      UniProtKB/TrEMBL
      A6KJB2
      Conserved Domains (3) summary
      pfam09336
      Location:634 → 674
      Vps4_C; Vps4 C terminal oligomerization domain
      pfam17862
      Location:593 → 624
      AAA_lid_3; AAA+ lid domain
      cd19525
      Location:383 → 568
      RecA-like_Figl-1; ATPase domain of Fidgetin-Like 1 (FIGL-1)

    2. NM_001393808.1 → NP_001380737.1  fidgetin-like protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 all encode the same protein.
      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      Q6GX84
      UniProtKB/TrEMBL
      A6KJB2
      Conserved Domains (3) summary
      pfam09336
      Location:634 → 674
      Vps4_C; Vps4 C terminal oligomerization domain
      pfam17862
      Location:593 → 624
      AAA_lid_3; AAA+ lid domain
      cd19525
      Location:383 → 568
      RecA-like_Figl-1; ATPase domain of Fidgetin-Like 1 (FIGL-1)

    3. NM_001393809.1 → NP_001380738.1  fidgetin-like protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      Q6GX84
      UniProtKB/TrEMBL
      A6KJB2
      Related
      ENSRNOP00000101365.1, ENSRNOT00000134653.1
      Conserved Domains (3) summary
      pfam09336
      Location:634 → 674
      Vps4_C; Vps4 C terminal oligomerization domain
      pfam17862
      Location:593 → 624
      AAA_lid_3; AAA+ lid domain
      cd19525
      Location:383 → 568
      RecA-like_Figl-1; ATPase domain of Fidgetin-Like 1 (FIGL-1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      90573090..90595342 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272954.1 → XP_063129024.1  fidgetin-like protein 1 isoform X3

    2. XM_006251477.5 → XP_006251539.1  fidgetin-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006251539.1

      UniProtKB/Swiss-Prot
      Q6GX84
      UniProtKB/TrEMBL
      A6KJB2
      Related
      ENSRNOP00000078689.1, ENSRNOT00000107994.2
      Conserved Domains (3) summary
      pfam09336
      Location:634 → 674
      Vps4_C; Vps4 C terminal oligomerization domain
      pfam17862
      Location:593 → 624
      AAA_lid_3; AAA+ lid domain
      cd19525
      Location:383 → 568
      RecA-like_Figl-1; ATPase domain of Fidgetin-Like 1 (FIGL-1)

    3. XM_063272953.1 → XP_063129023.1  fidgetin-like protein 1 isoform X2

      Related
      ENSRNOP00000005857.4, ENSRNOT00000005857.6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6GX84.1 GenPept UniProtKB/Swiss-Prot:Q6GX84

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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