Tada2b transcriptional adaptor 2B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tada2bprovided by RGD
Official Full Name: transcriptional adaptor 2Bprovided by RGD
Primary source: RGD:1561605
See related: AllianceGenome:RGD:1561605
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ADA2B; RGD1561605
Summary: Predicted to enable chromatin binding activity and transcription coactivator activity. Predicted to be involved in chromatin remodeling and regulation of transcription by RNA polymerase II. Predicted to be part of SAGA complex. Predicted to be active in nucleus. Orthologous to human TADA2B (transcriptional adaptor 2B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 77.5), Adrenal (RPKM 77.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (78503939..78523715)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (74279286..74290758)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (79446057..79457341)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of SAGA complex	ISO Inferred from Sequence Orthology more info
part_of SAGA-type complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SAGA-type complex	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transcriptional adapter 2-beta

Names: transcriptional adaptor 2 (ADA2 homolog, yeast)-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170455.1 → NP_001163926.1 transcriptional adapter 2-beta

See identical proteins and their annotated locations for NP_001163926.1

Status: VALIDATED

Source sequence(s)

AI136865, BC169109, FM069965

UniProtKB/TrEMBL

B5DFL8, F7EYV9

Conserved Domains (1) summary

COG5114
Location:6 → 415

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

78503939..78523715

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272942.1 → XP_063129012.1 transcriptional adapter 2-beta isoform X1

UniProtKB/TrEMBL

B5DFL8
XM_039091729.2 → XP_038947657.1 transcriptional adapter 2-beta isoform X2

UniProtKB/TrEMBL

A0A8I5ZQS6, A0A8I6AD48

Conserved Domains (1) summary

COG5114
Location:1 → 323

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]