Grem2 gremlin 2, DAN family BMP antagonist [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Grem2provided by RGD
Official Full Name: gremlin 2, DAN family BMP antagonistprovided by RGD
Primary source: RGD:1560008
See related: EnsemblRapid:ENSRNOG00000003616 AllianceGenome:RGD:1560008
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1560008
Summary: Predicted to enable several functions, including BMP binding activity; heparin binding activity; and identical protein binding activity. Predicted to be involved in several processes, including determination of dorsal identity; embryonic body morphogenesis; and regulation of signal transduction. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in tooth agenesis. Orthologous to human GREM2 (gremlin 2, DAN family BMP antagonist). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 118.0), Brain (RPKM 52.3) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (89310897..89403856, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (86778543..86871509, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (92894431..92988137, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LncRNA DNM3OS regulates GREM2 via miR-127-5p to suppress early chondrogenic differentiation of rat mesenchymal stem cells under hypoxic conditions.
Title: LncRNA DNM3OS regulates GREM2 via miR-127-5p to suppress early chondrogenic differentiation of rat mesenchymal stem cells under hypoxic conditions.
Suggest that Grem2 is a part of the signaling network of growth factors that regulate the primordial to primary follicle transition.
Title: Roles of Gremlin 1 and Gremlin 2 in regulating ovarian primordial to primary follicle transition.

Submit: New GeneRIF Correction

General gene information

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Markers

D13Mit4 (e-PCR), detects polymorphism
- UniSTS:119299

BF388208 (e-PCR)
- UniSTS:244871

BE110247 (e-PCR)
- UniSTS:245218

RH127350 (e-PCR)
- UniSTS:210660

RH140834 (e-PCR)
- UniSTS:210660

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables BMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables BMP binding	ISO Inferred from Sequence Orthology more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in determination of dorsal identity	ISO Inferred from Sequence Orthology more info
involved_in embryonic body morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokine activity	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytokine activity	ISO Inferred from Sequence Orthology more info
involved_in sequestering of BMP from receptor via BMP binding	IBA Inferred from Biological aspect of Ancestor more info
involved_in sequestering of BMP from receptor via BMP binding	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: gremlin-2

Names: gremlin 2 homolog, cysteine knot superfamily

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.