Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Ndufs2provided by RGD
Full Name: NADH:ubiquinone oxidoreductase core subunit S2provided by RGD
Primary source: RGD:1307109
See related: EnsemblRapid:ENSRNOG00000038372 AllianceGenome:RGD:1307109
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables oxygen sensor activity. Contributes to NADH dehydrogenase (ubiquinone) activity. Involved in cellular response to oxygen levels and mitochondrial electron transport, NADH to ubiquinone. Located in mitochondrial inner membrane. Part of respiratory chain complex I. Human ortholog(s) of this gene implicated in Leigh disease; hypertrophic cardiomyopathy; inherited metabolic disorder; multiple sclerosis; and nuclear type mitochondrial complex I deficiency 6. Orthologous to human NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 3146.1), Muscle (RPKM 2397.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (86186867..86203914, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (83654402..83671474, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (89606848..89623506, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ndufs2 (e-PCR), detects polymorphism
- UniSTS:527442

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables NAD binding	IEA Inferred from Electronic Annotation more info
contributes_to NADH dehydrogenase (ubiquinone) activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to NADH dehydrogenase (ubiquinone) activity	ISO Inferred from Sequence Orthology more info
enables NADH dehydrogenase (ubiquinone) activity	ISO Inferred from Sequence Orthology more info
enables NADH dehydrogenase (ubiquinone) activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to NADH dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on NAD(P)H	IEA Inferred from Electronic Annotation more info
enables oxygen sensor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxygen sensor activity	ISO Inferred from Sequence Orthology more info
enables quinone binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cellular response to oxygen levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to oxygen levels	ISO Inferred from Sequence Orthology more info
involved_in gliogenesis	ISO Inferred from Sequence Orthology more info
involved_in gliogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial ATP synthesis coupled electron transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial electron transport, NADH to ubiquinone	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, NADH to ubiquinone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial electron transport, NADH to ubiquinone	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respiratory chain complex I assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respiratory chain complex I assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in neural precursor cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in neurogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex I	IDA Inferred from Direct Assay more info	PubMed
part_of respiratory chain complex I	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

Names: CI-49kD; NADH dehydrogenase (ubiquinone) Fe-S protein 2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial-like; NADH-ubiquinone oxidoreductase 49 kDa subunit; complex I-49kD

NP_001011907.1

EC 7.1.1.2

XP_063128193.1

EC 7.1.1.2

XP_063128194.1

EC 7.1.1.2

XP_063128195.1

EC 7.1.1.2

XP_063128196.1

EC 7.1.1.2

XP_063128197.1

EC 7.1.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011907.1 → NP_001011907.1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial precursor

See identical proteins and their annotated locations for NP_001011907.1

Status: PROVISIONAL

Source sequence(s)

BC082067

UniProtKB/Swiss-Prot

Q641Y2

UniProtKB/TrEMBL

A0A8I6ABR8

Related

ENSRNOP00000090418.1, ENSRNOT00000094027.2

Conserved Domains (1) summary

PRK06075
Location:77 → 463

PRK06075; NADH-quinone oxidoreductase subunit D

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

86186867..86203914 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272126.1 → XP_063128196.1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1

UniProtKB/Swiss-Prot

Q641Y2
XM_063272125.1 → XP_063128195.1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1

UniProtKB/Swiss-Prot

Q641Y2
XM_063272123.1 → XP_063128193.1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1

UniProtKB/Swiss-Prot

Q641Y2

Related

ENSRNOP00000055224.4, ENSRNOT00000058423.6
XM_063272127.1 → XP_063128197.1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1

UniProtKB/Swiss-Prot

Q641Y2
XM_063272124.1 → XP_063128194.1 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1

UniProtKB/Swiss-Prot

Q641Y2