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    Gpr161 G protein-coupled receptor 161 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289180, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gpr161provided by RGD
    Official Full Name
    G protein-coupled receptor 161provided by RGD
    Primary source
    RGD:1563245
    See related
    EnsemblRapid:ENSRNOG00000003073 AllianceGenome:RGD:1563245
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563245
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning. Predicted to be located in cilium; glial cell projection; and neuron projection. Predicted to be active in plasma membrane and recycling endosome. Human ortholog(s) of this gene implicated in medulloblastoma. Orthologous to human GPR161 (G protein-coupled receptor 161). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 37.8), Lung (RPKM 31.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gpr161 in Genome Data Viewer
    Location:
    13q23
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (80111271..80156517)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (77578257..77623661)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (83530389..83576117)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene SFT2 domain containing 2 Neighboring gene TOR signaling pathway regulator Neighboring gene DDB1 and CUL4 associated factor 6 Neighboring gene mitochondrial pyruvate carrier 2 Neighboring gene adenylate cyclase 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling. Mukhopadhyay S, et al. Cell, 2013 Jan 17. PMID 23332756
    2. Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins. Badgandi HB, et al. J Cell Biol, 2017 Mar 6. PMID 28154160, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in glial cell projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    G protein-coupled receptor 161; G-protein coupled receptor 161

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      80111271..80156517
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272753.1 → XP_063128823.1  G-protein coupled receptor 161

      UniProtKB/TrEMBL
      F1M5Q2

    2. XM_063272754.1 → XP_063128824.1  G-protein coupled receptor 161

      UniProtKB/TrEMBL
      F1M5Q2
      Related
      ENSRNOP00000004104.6, ENSRNOT00000004104.8

    3. XM_017598995.3 → XP_017454484.1  G-protein coupled receptor 161

      UniProtKB/TrEMBL
      F1M5Q2
      Conserved Domains (1) summary
      cd15214
      Location:28 → 334
      7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001191672.1: Suppressed sequence

      Description
      NM_001191672.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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