Tfr2 transferrin receptor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tfr2provided by RGD
Official Full Name: transferrin receptor 2provided by RGD
Primary source: RGD:1310152
See related: EnsemblRapid:ENSRNOG00000001407 AllianceGenome:RGD:1310152
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Trfr2
Summary: Predicted to enable co-receptor binding activity and transferrin receptor activity. Involved in acute-phase response. Predicted to be located in cytoplasmic vesicle and plasma membrane. Predicted to be part of HFE-transferrin receptor complex. Predicted to be active in external side of plasma membrane. Used to study hemochromatosis type 3. Human ortholog(s) of this gene implicated in hemochromatosis and hemochromatosis type 3. Orthologous to human TFR2 (transferrin receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 776.2) and Spleen (RPKM 52.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 12q12

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (24744450..24761413, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (19107673..19124622, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (22177382..22194330, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of Slc19a1 and Tfr2 in liver transport of iron and folate: A rat model of folate/iron deficiency followed by supplementation.
Title: Role of Slc19a1 and Tfr2 in liver transport of iron and folate: A rat model of folate/iron deficiency followed by supplementation.
Repeated Restraint Stress Enhances Hepatic TFR2 Expression and Induces Hepatic Iron Accumulation in Rats.
Title: Repeated Restraint Stress Enhances Hepatic TFR2 Expression and Induces Hepatic Iron Accumulation in Rats.
A mutation with the Tfr2 gene causes hemochromatosis in the rat.
Title: A novel rat model of hereditary hemochromatosis due to a mutation in transferrin receptor 2.
we have discovered a novel mitochondrial iron transport system that goes awry in Parkinson's disease, and which may provide a new target for therapeutic intervention.
Title: A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease.
hemojuvelin and TfR2 were predominantly localized to the basolateral membrane domain of hepatocytes; localization of Hjv and TfR2 at the same membrane domain renders a functional interaction of these two proteins in iron homeostasis possible
Title: Localization of the iron-regulatory proteins hemojuvelin and transferrin receptor 2 to the basolateral membrane domain of hepatocytes.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables co-receptor binding	ISO Inferred from Sequence Orthology more info
enables transferrin receptor activity	IEA Inferred from Electronic Annotation more info
enables transferrin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acute-phase response	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to iron ion	ISO Inferred from Sequence Orthology more info
involved_in endocytic iron import into cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytic iron import into cell	ISO Inferred from Sequence Orthology more info
involved_in intracellular iron ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in multicellular organismal-level iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptide hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein maturation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in response to iron ion	ISO Inferred from Sequence Orthology more info
involved_in transferrin transport	IEA Inferred from Electronic Annotation more info
involved_in transferrin transport	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of HFE-transferrin receptor complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transferrin receptor protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105916.1 → NP_001099386.1 transferrin receptor protein 2

See identical proteins and their annotated locations for NP_001099386.1

Status: PROVISIONAL

Source sequence(s)

CH473973

UniProtKB/Swiss-Prot

B2GUY2

UniProtKB/TrEMBL

A0A8L2UQK5

Related

ENSRNOP00000001905.4, ENSRNOT00000001905.8

Conserved Domains (3) summary

cd09848
Location:404 → 637

M28_TfR; M28 Zn-peptidase Transferrin Receptor family

cd02128
Location:206 → 396

PA_TfR; PA_TfR: Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 ...

pfam04253
Location:669 → 788

TFR_dimer; Transferrin receptor-like dimerization domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

24744450..24761413 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008769127.3 → XP_008767349.1 transferrin receptor protein 2 isoform X3

UniProtKB/TrEMBL

A0A8L2UQK5

Related

ENSRNOP00000101579.1, ENSRNOT00000161275.1

Conserved Domains (3) summary

cd02128
Location:246 → 436

PA_TfR; PA_TfR: Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 ...

pfam04253
Location:633 → 752

TFR_dimer; Transferrin receptor-like dimerization domain

cl14876
Location:444 → 624

Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
XM_006249116.4 → XP_006249178.1 transferrin receptor protein 2 isoform X1

UniProtKB/TrEMBL

A0A8L2UQK5

Related

ENSRNOP00000106080.1, ENSRNOT00000124044.1

Conserved Domains (3) summary

cd09848
Location:444 → 677

M28_TfR; M28 Zn-peptidase Transferrin Receptor family

cd02128
Location:246 → 436

PA_TfR; PA_TfR: Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 ...

pfam04253
Location:709 → 828

TFR_dimer; Transferrin receptor-like dimerization domain
XM_008769125.4 → XP_008767347.1 transferrin receptor protein 2 isoform X2

See identical proteins and their annotated locations for XP_008767347.1

UniProtKB/Swiss-Prot

B2GUY2

UniProtKB/TrEMBL

A0A8L2UQK5

Conserved Domains (3) summary

cd09848
Location:404 → 637

M28_TfR; M28 Zn-peptidase Transferrin Receptor family

cd02128
Location:206 → 396

PA_TfR; PA_TfR: Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 ...

pfam04253
Location:669 → 788

TFR_dimer; Transferrin receptor-like dimerization domain
XM_006249117.4 → XP_006249179.1 transferrin receptor protein 2 isoform X2

See identical proteins and their annotated locations for XP_006249179.1

UniProtKB/Swiss-Prot

B2GUY2

UniProtKB/TrEMBL

A0A8L2UQK5

Conserved Domains (3) summary

cd09848
Location:404 → 637

M28_TfR; M28 Zn-peptidase Transferrin Receptor family

cd02128
Location:206 → 396

PA_TfR; PA_TfR: Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 ...

pfam04253
Location:669 → 788

TFR_dimer; Transferrin receptor-like dimerization domain
XM_006249118.2 → XP_006249180.1 transferrin receptor protein 2 isoform X2

See identical proteins and their annotated locations for XP_006249180.1

UniProtKB/Swiss-Prot

B2GUY2

UniProtKB/TrEMBL

A0A8L2UQK5

Conserved Domains (3) summary

cd09848
Location:404 → 637

M28_TfR; M28 Zn-peptidase Transferrin Receptor family

cd02128
Location:206 → 396

PA_TfR; PA_TfR: Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 ...

pfam04253
Location:669 → 788

TFR_dimer; Transferrin receptor-like dimerization domain