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    Qtrt2 queuine tRNA-ribosyltransferase accessory subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288364, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Qtrt2provided by RGD
    Official Full Name
    queuine tRNA-ribosyltransferase accessory subunit 2provided by RGD
    Primary source
    RGD:1310054
    See related
    EnsemblRapid:ENSRNOG00000060729 AllianceGenome:RGD:1310054
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Qtrtd1
    Summary
    Predicted to enable protein heterodimerization activity; protein homodimerization activity; and tRNA binding activity. Predicted to be involved in tRNA-guanine transglycosylation. Predicted to be located in mitochondrion. Predicted to be part of tRNA-guanine transglycosylase complex. Orthologous to human QTRT2 (queuine tRNA-ribosyltransferase accessory subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 39.9), Thymus (RPKM 32.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Qtrt2 in Genome Data Viewer
    Location:
    11q21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (70312352..70343139)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (56806417..56837239)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (61748822..61779631)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene zinc finger DHHC-type palmitoyltransferase 23 Neighboring gene coiled-coil domain containing 191 Neighboring gene small nucleolar RNA, H/ACA box 84 Neighboring gene uncharacterized LOC134480927 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of the human tRNA-guanine transglycosylase: confirmation of the heterodimeric subunit structure. Chen YC, et al. RNA, 2010 May. PMID 20354154, Free PMC Article
    2. Queuosine formation in eukaryotic tRNA occurs via a mitochondria-localized heteromeric transglycosylase. Boland C, et al. J Biol Chem, 2009 Jul 3. PMID 19414587, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA-guanosine(34) queuine transglycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA-guanine transglycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA-guanine transglycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic side of mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of tRNA-guanine transglycosylase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    queuine tRNA-ribosyltransferase accessory subunit 2
    Names
    queuine tRNA-ribosyltransferase domain containing 1
    queuine tRNA-ribosyltransferase subunit QTRTD1
    NP_001292082.1
    XP_006248382.1
    XP_008766981.1
    XP_008766982.1
    XP_008766983.1
    XP_008766984.1
    XP_038944159.1
    XP_038944161.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305153.1 → NP_001292082.1  queuine tRNA-ribosyltransferase accessory subunit 2

      See identical proteins and their annotated locations for NP_001292082.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A1W2Q6P4, A6IR22, M0RB91
      Conserved Domains (1) summary
      pfam01702
      Location:14 → 415
      TGT; Queuine tRNA-ribosyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      70312352..70343139
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088231.2 → XP_038944159.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform X1

      UniProtKB/TrEMBL
      M0RB91
      Conserved Domains (1) summary
      pfam01702
      Location:14 → 428
      TGT; Queuine tRNA-ribosyltransferase

    2. XM_039088233.2 → XP_038944161.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform X2

      UniProtKB/TrEMBL
      A0A1W2Q6P4, A6IR22, M0RB91
      Conserved Domains (1) summary
      pfam01702
      Location:14 → 415
      TGT; Queuine tRNA-ribosyltransferase

    3. XM_008768759.4 → XP_008766981.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform X1

      See identical proteins and their annotated locations for XP_008766981.1

      UniProtKB/TrEMBL
      M0RB91
      Related
      ENSRNOP00000076331.3, ENSRNOT00000093719.3
      Conserved Domains (1) summary
      pfam01702
      Location:14 → 428
      TGT; Queuine tRNA-ribosyltransferase

    4. XM_008768760.4 → XP_008766982.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform X3

      Conserved Domains (1) summary
      pfam01702
      Location:119 → 351
      TGT; Queuine tRNA-ribosyltransferase

    5. XM_008768761.4 → XP_008766983.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform X4

      UniProtKB/TrEMBL
      D3ZBQ4
      Related
      ENSRNOP00000076283.1, ENSRNOT00000093552.3
      Conserved Domains (1) summary
      pfam01702
      Location:119 → 338
      TGT; Queuine tRNA-ribosyltransferase

    6. XM_006248320.5 → XP_006248382.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform X2

      See identical proteins and their annotated locations for XP_006248382.1

      UniProtKB/TrEMBL
      A0A1W2Q6P4, A6IR22, M0RB91
      Conserved Domains (1) summary
      pfam01702
      Location:14 → 415
      TGT; Queuine tRNA-ribosyltransferase

    7. XM_008768762.2 → XP_008766984.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform X5

      See identical proteins and their annotated locations for XP_008766984.1

      Conserved Domains (1) summary
      pfam01702
      Location:48 → 335
      TGT; Queuine tRNA-ribosyltransferase

    RNA

    1. XR_005491014.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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