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    Sidt1 SID1 transmembrane family, member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288109, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Sidt1provided by RGD
    Official Full Name
    SID1 transmembrane family, member 1provided by RGD
    Primary source
    RGD:1559616
    See related
    EnsemblRapid:ENSRNOG00000002013 AllianceGenome:RGD:1559616
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA transmembrane transporter activity; cholesterol binding activity; and double-stranded RNA binding activity. Predicted to be involved in RNA transport. Predicted to be located in membrane. Predicted to be active in lysosome and plasma membrane. Orthologous to human SIDT1 (SID1 transmembrane family member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 65.0), Thymus (RPKM 18.6) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sidt1 in Genome Data Viewer
    Location:
    11q21
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (69867758..69965377)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (56362788..56459939)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (61320480..61416560)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 44 Neighboring gene uncharacterized LOC134481069 Neighboring gene spindle and centriole associated protein 1 Neighboring gene U2 spliceosomal RNA Neighboring gene upstream transcription factor family member 3 Neighboring gene N(alpha)-acetyltransferase 50, NatE catalytic subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel family of mammalian transmembrane proteins involved in cholesterol transport. Méndez-Acevedo KM, et al. Sci Rep, 2017 Aug 7. PMID 28785058, Free PMC Article
    2. Systemic RNA Interference Deficiency-1 (SID-1) Extracellular Domain Selectively Binds Long Double-stranded RNA and Is Required for RNA Transport by SID-1. Li W, et al. J Biol Chem, 2015 Jul 31. PMID 26067272, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cholesterol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SID1 transmembrane family member 1
    Names
    Msid2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100653.1 → NP_001094123.1  SID1 transmembrane family member 1 precursor

      See identical proteins and their annotated locations for NP_001094123.1

      Status: VALIDATED

      Source sequence(s)
      AY562215, BE112870, JAXUCZ010000011
      UniProtKB/Swiss-Prot
      Q6Q3F5
      UniProtKB/TrEMBL
      D4A117
      Conserved Domains (1) summary
      pfam13965
      Location:187 → 810
      SID-1_RNA_chan; dsRNA-gated channel SID-1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      69867758..69965377
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597923.3 → XP_017453412.1  SID1 transmembrane family member 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A153, D4A117
      Related
      ENSRNOP00000112686.1, ENSRNOT00000131276.1

    2. XM_006248328.5 → XP_006248390.1  SID1 transmembrane family member 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ADX2, D4A117
      Related
      ENSRNOP00000085335.2, ENSRNOT00000098261.2
      Conserved Domains (1) summary
      pfam13965
      Location:187 → 806
      SID-1_RNA_chan; dsRNA-gated channel SID-1

    3. XM_039088181.2 → XP_038944109.1  SID1 transmembrane family member 1 isoform X3

      UniProtKB/TrEMBL
      D4A117
      Related
      ENSRNOP00000092423.2, ENSRNOT00000095341.2
      Conserved Domains (1) summary
      pfam13965
      Location:184 → 787
      SID-1_RNA_chan; dsRNA-gated channel SID-1

    4. XM_063270390.1 → XP_063126460.1  SID1 transmembrane family member 1 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6Q3F5.2 GenPept UniProtKB/Swiss-Prot:Q6Q3F5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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