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    PLCB1 phospholipase C beta 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 287026, updated on 10-Oct-2024

    Summary

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    Official Symbol
    PLCB1provided by VGNC
    Official Full Name
    phospholipase C beta 1provided by VGNC
    Primary source
    VGNC:VGNC:32980
    See related
    BGD:BT29800; Ensembl:ENSBTAG00000008338
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PLCB1 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (932890..1794155)

    Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132346868 Neighboring gene uncharacterized LOC112449369 Neighboring gene microRNA mir-2285m-1 Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene uncharacterized LOC112449370 Neighboring gene phospholipase C beta 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Determination of the primary structure of PLC-154 demonstrates diversity of phosphoinositide-specific phospholipase C activities. Katan M, et al. Cell, 1988 Jul 15. PMID 2455601
    2. Investigation of high correlation with carcass traits of SNPs of the PLCB1, C/EBPα, and TDRKH genes and the combinations of SNPs using the MDR method in the Hanwoo. Kim S, et al. Genes Genomics, 2021 Aug. PMID 34129193
    3. Concentration of enzyme-dependent activation of PLC-beta 1 and PLC-beta 2 by G alpha 11 and beta gamma-subunits. Paterson A, et al. Cell Signal, 1995 Sep. PMID 8519600
    4. Tyrosine phosphorylation of phospholipase C-II in vitro by the epidermal growth factor receptor. Nishibe S, et al. J Biol Chem, 1989 Jun 25. PMID 2732223
    5. Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF. Tang Y, et al. J Biol Chem, 2000 Dec 1. PMID 10980202

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Investigation of high correlation with carcass traits of SNPs of the PLCB1, C/EBPalpha, and TDRKH genes and the combinations of SNPs using the MDR method in the Hanwoo.
      Title: Investigation of high correlation with carcass traits of SNPs of the PLCB1, C/EBPα, and TDRKH genes and the combinations of SNPs using the MDR method in the Hanwoo.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in memory IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
    Names
    PLC-154
    PLC-I
    PLC-beta-1
    phosphoinositide phospholipase C
    phosphoinositide phospholipase C-beta-1
    phospholipase C, beta 1 (phosphoinositide-specific)
    NP_777242.1
    XP_059748385.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174817.1 → NP_777242.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

      See identical proteins and their annotated locations for NP_777242.1

      Status: PROVISIONAL

      Source sequence(s)
      J03137
      UniProtKB/Swiss-Prot
      P10894
      UniProtKB/TrEMBL
      A0A3Q1NG00
      Related
      ENSBTAP00000058710.2, ENSBTAT00000078977.2
      Conserved Domains (7) summary
      cd00275
      Location:677 → 796
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:316 → 643
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02952
      Location:216 → 784
      PLN02952; phosphoinositide phospholipase C
      cd13361
      Location:22 → 148
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam06631
      Location:903 → 939
      DUF1154; Protein of unknown function (DUF1154)
      pfam08703
      Location:1003 → 1172
      PLC-beta_C; PLC-beta C terminal
      pfam09279
      Location:224 → 314
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      932890..1794155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059892402.1 → XP_059748385.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1

      UniProtKB/TrEMBL
      A0AAF6ZHX3
      Related
      ENSBTAP00000046644.4, ENSBTAT00000049812.5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10894.1 GenPept UniProtKB/Swiss-Prot:P10894

    Gene LinkOut

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