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    PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 287019, updated on 4-Oct-2024

    Summary

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    Official Symbol
    PFKFB2provided by VGNC
    Official Full Name
    6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2provided by VGNC
    Primary source
    VGNC:VGNC:32770
    See related
    BGD:BT10753; Ensembl:ENSBTAG00000002126
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PFKFB2 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 16 NC_037343.1 (4871974..4900744)

    Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene chromosome 16 C1orf116 homolog Neighboring gene YOD1 deubiquitinase Neighboring gene transfer RNA glutamic acid (anticodon CUC) Neighboring gene complement component 4 binding protein beta Neighboring gene complement component 4 binding protein alpha

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and expression of novel isoforms of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase from bovine heart. Vidal H, et al. FEBS Lett, 1993 Sep 20. PMID 8397106
    2. Bovine heart fructose 6-P,2-kinase:fructose 2,6-bisphosphatase mRNA and gene structure. Tsuchiya Y, et al. Arch Biochem Biophys, 1994 May 1. PMID 8179334
    3. Phosphorylation of myocardial fructose-6-phosphate,2-kinase: fructose-2,6-bisphosphatase by cAMP-dependent protein kinase and protein kinase C. Activation by phosphorylation and amino acid sequences of the phosphorylation sites. Kitamura K, et al. J Biol Chem, 1988 Nov 15. PMID 2846551
    4. Bovine heart fructose-6-phosphate 2-kinase/fructose-2,6-bisphosphatase: complete amino acid sequence and localization of phosphorylation sites. Sakata J, et al. Proc Natl Acad Sci U S A, 1990 Jul. PMID 2164212, Free PMC Article
    5. Characterization of two isozymic forms of heart fructose 6-phosphate, 2-kinase:fructose 2,6-bisphosphatase. Sakata J, et al. Biochem Biophys Res Commun, 1991 Oct 31. PMID 1659398

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crystal structure of human and cattle heart PFKFB2 and the inhibitory influence of citrate on substrate binding has been described.
      Title: Crystal structure of heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB2) and the inhibitory influence of citrate on substrate binding.
    2. SGK3 is not required for insulin-induced PFK-2 activation and that this effect is likely mediated by PKBalpha.
      Title: Heart 6-phosphofructo-2-kinase activation by insulin requires PKB (protein kinase B), but not SGK3 (serum- and glucocorticoid-induced protein kinase 3).
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 6-phosphofructo-2-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables fructose-2,6-bisphosphate 2-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fructose 2,6-bisphosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in fructose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
    Names
    6-phosphofructo-2-kinase /fructose-2,6-bisphosphatase
    6PF-2-K/Fru-2,6-P2ASE heart-type isozyme
    6PF-2-K/Fru-2,6-P2ase 2
    PFK-2/FBPase-2
    PFK/FBPase 2
    NP_777237.3
    XP_005216711.1
    XP_005216712.1
    XP_005216714.1
    XP_010811317.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174812.4 → NP_777237.3  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2

      See identical proteins and their annotated locations for NP_777237.3

      Status: PROVISIONAL

      Source sequence(s)
      S70453
      UniProtKB/Swiss-Prot
      P26285
      UniProtKB/TrEMBL
      A0A3Q1MTT6
      Related
      ENSBTAP00000002753.2, ENSBTAT00000002753.3
      Conserved Domains (3) summary
      pfam00300
      Location:253 → 436
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:27 → 250
      6PF2K; 6-phosphofructo-2-kinase
      pfam13671
      Location:41 → 196
      AAA_33; AAA domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      4871974..4900744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005216655.5 → XP_005216712.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform X1

      See identical proteins and their annotated locations for XP_005216712.1

      UniProtKB/TrEMBL
      A0A3Q1MTT6
      Conserved Domains (3) summary
      pfam00300
      Location:253 → 436
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:27 → 250
      6PF2K; 6-phosphofructo-2-kinase
      pfam13671
      Location:41 → 196
      AAA_33; AAA domain

    2. XM_005216654.4 → XP_005216711.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform X1

      See identical proteins and their annotated locations for XP_005216711.1

      UniProtKB/TrEMBL
      A0A3Q1MTT6
      Conserved Domains (3) summary
      pfam00300
      Location:253 → 436
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:27 → 250
      6PF2K; 6-phosphofructo-2-kinase
      pfam13671
      Location:41 → 196
      AAA_33; AAA domain

    3. XM_005216657.4 → XP_005216714.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform X2

      See identical proteins and their annotated locations for XP_005216714.1

      UniProtKB/TrEMBL
      A0A3Q1LJP5, A6QL99
      Related
      ENSBTAP00000050645.1, ENSBTAT00000053481.3
      Conserved Domains (3) summary
      pfam00300
      Location:253 → 436
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:27 → 250
      6PF2K; 6-phosphofructo-2-kinase
      pfam13671
      Location:41 → 196
      AAA_33; AAA domain

    4. XM_010813015.3 → XP_010811317.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform X1

      See identical proteins and their annotated locations for XP_010811317.1

      UniProtKB/TrEMBL
      A0A3Q1MTT6
      Conserved Domains (3) summary
      pfam00300
      Location:253 → 436
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:27 → 250
      6PF2K; 6-phosphofructo-2-kinase
      pfam13671
      Location:41 → 196
      AAA_33; AAA domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P26285.2 GenPept UniProtKB/Swiss-Prot:P26285

    Gene LinkOut

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