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    SLC12A2 solute carrier family 12 member 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 286845, updated on 4-Oct-2024

    Summary

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    Official Symbol
    SLC12A2provided by VGNC
    Official Full Name
    solute carrier family 12 member 2provided by VGNC
    Primary source
    VGNC:VGNC:34665
    See related
    Ensembl:ENSBTAG00000009637
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    bsc2
    Orthologs
    human mouse all
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    Genomic context

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    See SLC12A2 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (25758860..25853058, complement)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene fibrillin 2 Neighboring gene U6 spliceosomal RNA Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene coiled-coil domain containing 192 Neighboring gene uncharacterized LOC107132618 Neighboring gene microRNA mir-12007

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of the Na-K-Cl cotransporter of bovine aortic endothelial cells. Yerby TR, et al. Am J Physiol, 1997 Jul. PMID 9252456
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ammonium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables sodium:potassium:chloride symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell volume homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in chloride ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in potassium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in potassium ion import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sodium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    solute carrier family 12 member 2
    Names
    basolateral NaK(2Cl) cotransporter
    solute carrier family 12 (sodium/potassium/chloride transporters), member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174782.3 → NP_777207.1  solute carrier family 12 member 2

      See identical proteins and their annotated locations for NP_777207.1

      Status: PROVISIONAL

      Source sequence(s)
      U70138
      UniProtKB/TrEMBL
      A0AAA9TKB1, O18978
      Related
      ENSBTAP00000097637.1, ENSBTAT00000106160.1
      Conserved Domains (3) summary
      TIGR00930
      Location:208 → 1201
      2a30; K-Cl cotransporter
      pfam03522
      Location:793 → 1201
      SLC12; Solute carrier family 12
      pfam08403
      Location:194 → 255
      AA_permease_N; Amino acid permease N-terminal

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      25758860..25853058 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005209087.4 → XP_005209144.1  solute carrier family 12 member 2 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1LSK1, A0AAA9TKB1
      Related
      ENSBTAP00000060229.1, ENSBTAT00000082866.2
      Conserved Domains (3) summary
      TIGR00930
      Location:208 → 1188
      2a30; K-Cl cotransporter
      pfam03522
      Location:793 → 1188
      SLC12; Solute carrier family 12
      pfam08403
      Location:194 → 255
      AA_permease_N; Amino acid permease N-terminal

    2. XM_005209086.4 → XP_005209143.1  solute carrier family 12 member 2 isoform X1

      UniProtKB/TrEMBL
      A0AAA9TKB1, F1MS08
      Related
      ENSBTAP00000012701.5, ENSBTAT00000012701.6
      Conserved Domains (3) summary
      TIGR00930
      Location:208 → 1204
      2a30; K-Cl cotransporter
      pfam03522
      Location:793 → 1204
      SLC12; Solute carrier family 12
      pfam08403
      Location:194 → 255
      AA_permease_N; Amino acid permease N-terminal
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Research Materials