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    FAM133A family with sequence similarity 133 member A [ Homo sapiens (human) ]

    Gene ID: 286499, updated on 19-Sep-2024

    Summary

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    Official Symbol
    FAM133Aprovided by HGNC
    Official Full Name
    family with sequence similarity 133 member Aprovided by HGNC
    Primary source
    HGNC:HGNC:26748
    See related
    Ensembl:ENSG00000179083 AllianceGenome:HGNC:26748
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT115
    Expression
    Biased expression in testis (RPKM 2.8), brain (RPKM 1.0) and 2 other tissues See more
    Orthologs
    all
    NEW
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    Genomic context

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    See FAM133A in Genome Data Viewer
    Location:
    Xq21.32
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (93673681..93712265)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (92118892..92157407)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (92929205..92967264)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:92840114-92841313 Neighboring gene ribosomal protein L7 pseudogene 55 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:92882347-92882848 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:92891704-92892690 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:92892691-92893676 Neighboring gene nucleosome assembly protein 1 like 3 Neighboring gene USP37 pseudogene 1 Neighboring gene RNA, U6 small nuclear 332, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Folate receptor α increases chemotherapy resistance through stabilizing MDM2 in cooperation with PHB2 that is overcome by MORAb-202 in gastric cancer. Sakai H, et al. Clin Transl Med, 2021 Jun. PMID 34185411, Free PMC Article
    2. Histone-binding of DPF2 mediates its repressive role in myeloid differentiation. Huber FM, et al. Proc Natl Acad Sci U S A, 2017 Jun 6. PMID 28533407, Free PMC Article
    3. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Yachie N, et al. Mol Syst Biol, 2016 Apr 22. PMID 27107012, Free PMC Article
    4. Assessment of community efforts to advance network-based prediction of protein-protein interactions. Wang XW, et al. Nat Commun, 2023 Mar 22. PMID 36949045, Free PMC Article
    5. A protein interaction landscape of breast cancer. Kim M, et al. Science, 2021 Oct. PMID 34591612, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ37659

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein FAM133A
    Names
    cancer/testis antigen 115

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016400.1 RefSeqGene

      Range
      5194..43253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001171109.2 → NP_001164580.1  protein FAM133A

      See identical proteins and their annotated locations for NP_001164580.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AL009173, DA414074
      Consensus CDS
      CCDS14466.1
      UniProtKB/Swiss-Prot
      Q8N9E0
      Related
      ENSP00000507109.1, ENST00000683942.1

    2. NM_001171110.2 → NP_001164581.1  protein FAM133A

      See identical proteins and their annotated locations for NP_001164581.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AL009173, DA188870
      Consensus CDS
      CCDS14466.1
      UniProtKB/Swiss-Prot
      Q8N9E0

    3. NM_001171111.2 → NP_001164582.1  protein FAM133A

      See identical proteins and their annotated locations for NP_001164582.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AL009173, DB084469
      Consensus CDS
      CCDS14466.1
      UniProtKB/Swiss-Prot
      Q8N9E0
      Related
      ENSP00000318974.4, ENST00000322139.4

    4. NM_173698.3 → NP_775969.1  protein FAM133A

      See identical proteins and their annotated locations for NP_775969.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AL009173, DA297338
      Consensus CDS
      CCDS14466.1
      UniProtKB/Swiss-Prot
      Q8N9E0
      Related
      ENSP00000362169.1, ENST00000332647.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      93673681..93712265
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011530926.4 → XP_011529228.1  protein FAM133A isoform X1

      See identical proteins and their annotated locations for XP_011529228.1

      UniProtKB/Swiss-Prot
      Q8N9E0

    2. XM_011530927.3 → XP_011529229.1  protein FAM133A isoform X1

      See identical proteins and their annotated locations for XP_011529229.1

      UniProtKB/Swiss-Prot
      Q8N9E0

    3. XM_011530929.2 → XP_011529231.1  protein FAM133A isoform X1

      See identical proteins and their annotated locations for XP_011529231.1

      UniProtKB/Swiss-Prot
      Q8N9E0

    4. XM_017029454.2 → XP_016884943.1  protein FAM133A isoform X1

      UniProtKB/Swiss-Prot
      Q8N9E0

    5. XM_017029455.2 → XP_016884944.1  protein FAM133A isoform X1

      UniProtKB/Swiss-Prot
      Q8N9E0

    6. XM_011530928.2 → XP_011529230.1  protein FAM133A isoform X1

      See identical proteins and their annotated locations for XP_011529230.1

      UniProtKB/Swiss-Prot
      Q8N9E0

    7. XM_011530925.3 → XP_011529227.1  protein FAM133A isoform X1

      See identical proteins and their annotated locations for XP_011529227.1

      UniProtKB/Swiss-Prot
      Q8N9E0

    8. XM_017029456.2 → XP_016884945.1  protein FAM133A isoform X1

      UniProtKB/Swiss-Prot
      Q8N9E0

    9. XM_006724641.4 → XP_006724704.1  protein FAM133A isoform X1

      See identical proteins and their annotated locations for XP_006724704.1

      UniProtKB/Swiss-Prot
      Q8N9E0

    10. XM_011530931.3 → XP_011529233.1  protein FAM133A isoform X1

      See identical proteins and their annotated locations for XP_011529233.1

      UniProtKB/Swiss-Prot
      Q8N9E0

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      92118892..92157407
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326903.1 → XP_054182878.1  protein FAM133A isoform X1

      UniProtKB/Swiss-Prot
      Q8N9E0

    2. XM_054326902.1 → XP_054182877.1  protein FAM133A isoform X1

      UniProtKB/Swiss-Prot
      Q8N9E0

    3. XM_054326910.1 → XP_054182885.1  protein FAM133A isoform X1

      UniProtKB/Swiss-Prot
      Q8N9E0

    4. XM_054326909.1 → XP_054182884.1  protein FAM133A isoform X1

      UniProtKB/Swiss-Prot
      Q8N9E0

    5. XM_054326906.1 → XP_054182881.1  protein FAM133A isoform X1

      UniProtKB/Swiss-Prot
      Q8N9E0

    6. XM_054326908.1 → XP_054182883.1  protein FAM133A isoform X1

      UniProtKB/Swiss-Prot
      Q8N9E0

    7. XM_054326904.1 → XP_054182879.1  protein FAM133A isoform X1

      UniProtKB/Swiss-Prot
      Q8N9E0

    8. XM_054326907.1 → XP_054182882.1  protein FAM133A isoform X1

      UniProtKB/Swiss-Prot
      Q8N9E0

    9. XM_054326905.1 → XP_054182880.1  protein FAM133A isoform X1

      UniProtKB/Swiss-Prot
      Q8N9E0

    10. XM_054326911.1 → XP_054182886.1  protein FAM133A isoform X1

      UniProtKB/Swiss-Prot
      Q8N9E0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N9E0.1 GenPept UniProtKB/Swiss-Prot:Q8N9E0

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