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    PTGR3 prostaglandin reductase 3 [ Homo sapiens (human) ]

    Gene ID: 284273, updated on 14-Nov-2024

    Summary

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    Official Symbol
    PTGR3provided by HGNC
    Official Full Name
    prostaglandin reductase 3provided by HGNC
    Primary source
    HGNC:HGNC:28697
    See related
    Ensembl:ENSG00000180011 MIM:620604; AllianceGenome:HGNC:28697
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRG-3; ZADH2; PTGR-3
    Summary
    Predicted to enable 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity. Predicted to be involved in negative regulation of fat cell differentiation. Located in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta (RPKM 7.9), thyroid (RPKM 6.9) and 25 other tissues See more
    Orthologs
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    Genomic context

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    See PTGR3 in Genome Data Viewer
    Location:
    18q22.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (75195108..75209139, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (75424502..75438532, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (72907063..72921094, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904325 Neighboring gene uncharacterized LOC124904326 Neighboring gene uncharacterized LOC105376874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:72882003-72882504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:72882505-72883004 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:72916583-72917576 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:72920599-72921529 Neighboring gene Sharpr-MPRA regulatory region 3936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9549 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:72947291-72948490 Neighboring gene teashirt zinc finger homeobox 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13506 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:72985503-72986004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:72986005-72986504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:72990985-72991486 Neighboring gene Sharpr-MPRA regulatory region 9768 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr18:73061340-73062286 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr18:73062287-73063231 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:73072069-73072610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:73072611-73073151 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:73090414-73090914 Neighboring gene uncharacterized LOC105372200 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:73120415-73121614 Neighboring gene small integral membrane protein 21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. [Mechanism of miRNA-3679 Inhibiting Downstream ZADH2-Target Genes to Promote Hepatocellular Carcinoma Cell Proliferation]. He JY, et al. Sichuan Da Xue Xue Bao Yi Xue Ban, 2022 Sep. PMID 36224673, Free PMC Article
    2. DNA Hypomethylation in Blood Links B3GALT4 and ZADH2 to Alzheimer's Disease. Madrid A, et al. J Alzheimers Dis, 2018. PMID 30372681, Free PMC Article
    3. Thermal proteome profiling identifies PIP4K2A and ZADH2 as off-targets of Polo-like kinase 1 inhibitor volasertib. Goroshchuk O, et al. FASEB J, 2021 Jul. PMID 34143546
    4. Prostaglandin reductase-3 negatively modulates adipogenesis through regulation of PPARγ activity. Yu YH, et al. J Lipid Res, 2013 Sep. PMID 23821743, Free PMC Article
    5. Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping. McDonough CW, et al. Hum Genet, 2009 Dec. PMID 19690890, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [Mechanism of miRNA-3679 Inhibiting Downstream ZADH2-Target Genes to Promote Hepatocellular Carcinoma Cell Proliferation].
      Title: [Mechanism of miRNA-3679 Inhibiting Downstream ZADH2-Target Genes to Promote Hepatocellular Carcinoma Cell Proliferation].
    2. Thermal proteome profiling identifies PIP4K2A and ZADH2 as off-targets of Polo-like kinase 1 inhibitor volasertib.
      Title: Thermal proteome profiling identifies PIP4K2A and ZADH2 as off-targets of Polo-like kinase 1 inhibitor volasertib.
    3. In patients with late-onset Alzheimer disease, a number of differentially methylated postitions were hypomethylated in ZADH2 compared with controls.
      Title: DNA Hypomethylation in Blood Links B3GALT4 and ZADH2 to Alzheimer's Disease.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC45594

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HTP PubMed 
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    prostaglandin reductase 3
    Names
    zinc binding alcohol dehydrogenase domain containing 2
    zinc-binding alcohol dehydrogenase domain-containing protein 2
    NP_001293022.1
    NP_787103.1
    XP_024306934.1
    XP_054174512.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001306093.1 → NP_001293022.1  prostaglandin reductase 3 isoform 2

      See identical proteins and their annotated locations for NP_001293022.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC025105, AK302801, BU682476, BX647730
      Consensus CDS
      CCDS77198.1
      UniProtKB/Swiss-Prot
      Q8N4Q0
      Related
      ENSP00000440111.2, ENST00000537114.2
      Conserved Domains (1) summary
      cl16912
      Location:1 → 245
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

    2. NM_175907.6 → NP_787103.1  prostaglandin reductase 3 isoform 1

      See identical proteins and their annotated locations for NP_787103.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC025105, BC018081, BU682476
      Consensus CDS
      CCDS12008.1
      UniProtKB/Swiss-Prot
      A8KA15, B4DZ91, Q8N4Q0
      UniProtKB/TrEMBL
      Q4G1C4
      Related
      ENSP00000323678.3, ENST00000322342.4
      Conserved Domains (1) summary
      cd08250
      Location:32 → 368
      Mgc45594_like; Mgc45594 gene product and other MDR family members

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      75195108..75209139 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451166.2 → XP_024306934.1  prostaglandin reductase 3 isoform X1

      Conserved Domains (1) summary
      cl16912
      Location:1 → 245
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      75424502..75438532 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054318537.1 → XP_054174512.1  prostaglandin reductase 3 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N4Q0.1 GenPept UniProtKB/Swiss-Prot:Q8N4Q0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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