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    MMP9 matrix metallopeptidase 9 [ Bos taurus (domestic cattle) ]

    Gene ID: 282871, updated on 4-Oct-2024

    Summary

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    Official Symbol
    MMP9provided by VGNC
    Official Full Name
    matrix metallopeptidase 9provided by VGNC
    Primary source
    VGNC:VGNC:31531
    See related
    BGD:BT11364; Ensembl:ENSBTAG00000020676
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See MMP9 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (74746991..74754302)

    Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene cathepsin A Neighboring gene phospholipid transfer protein Neighboring gene phosphorylated CTD interacting factor 1 Neighboring gene zinc finger protein 335 Neighboring gene solute carrier family 12 member 5 Neighboring gene nuclear receptor coactivator 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Infection with Theileria annulata induces expression of matrix metalloproteinase 9 and transcription factor AP-1 in bovine leucocytes. Baylis HA, et al. Mol Biochem Parasitol, 1995 Feb. PMID 7770085
    2. Expression of matrix metalloproteinase-9 mRNA and protein during deciduous tooth resorption in bovine odontoclasts. Linsuwanont B, et al. Bone, 2002 Oct. PMID 12398942
    3. Matrix metalloproteinase- 9 may contribute to collagen structure modification during postmortem aging of beef. Koulicoff LA, et al. Meat Sci, 2023 Nov. PMID 37643525
    4. Gelatinase (MMP-2 and -9) expression profiles during gestation in the bovine endometrium. Kizaki K, et al. Reprod Biol Endocrinol, 2008 Dec 31. PMID 19116037, Free PMC Article
    5. Matrix metalloproteinases-2 and -9 activities in bovine follicular fluid of different-sized follicles: relationship to intra-follicular inhibin and steroid concentrations. Imai K, et al. Domest Anim Endocrinol, 2003 Mar. PMID 12586316

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Matrix metalloproteinase- 9 may contribute to collagen structure modification during postmortem aging of beef.
      Title: Matrix metalloproteinase- 9 may contribute to collagen structure modification during postmortem aging of beef.
    2. In diabetic retinopathy transcription of MMP-9 is regulated by AP-1 binding at both, proximal and distal sites of its promoter, and acetylation of c-Jun and c-Fos subunits is important in its regulation.
      Title: Molecular Mechanism of Transcriptional Regulation of Matrix Metalloproteinase-9 in Diabetic Retinopathy.
    3. These data demonstrate that serum neutrophil haptoglobin-MMP 9 complexes appear sooner and decline more rapidly than other acute phase proteins.
      Title: Characterization of the contributions of Hp-MMP 9 to the serum acute phase protein response of lipopolysaccharide challenged calves.
    4. Activation of cytosolic MMP-9 and MMP-2 was investigated in the retinal endothelial cells incubated in high glucose for 6-96 h, and correlated with their mitochondrial accumulation and mitochondrial damage.
      Title: Interrelationship between activation of matrix metalloproteinases and mitochondrial dysfunction in the development of diabetic retinopathy.
    5. Role of TGF-beta1 and TNF-alpha in IL-1beta mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease.
      Title: Role of TGF-β1 and TNF-α in IL-1β mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease.
    6. Decreased MMP-9 and increased TIMP-1 expression were found in peripheral blood cells from Mycobacterium avium subsp. paratuberculosis (Map)-infected cattle after stimulation with Map lysate and Map purified protein derivative than in control cattle.
      Title: Decreased expression of matrix metalloproteinase-9 and increased expression of tissue inhibitors of matrix metalloproteinase-1 in paratuberculosis-infected cattle in the ELISA-negative subclinical stage.
    7. We used a trophoblast cell line (F3) derived from bovine placentomes to examine the influence of EGF on MMP-9 and TIMP-1 expression by semiquantitative RT-PCR and MMP activity by zymography.
      Title: Epidermal growth factor (EGF) induces motility and upregulates MMP-9 and TIMP-1 in bovine trophoblast cells.
    8. The expression level of MMP-9 was stably maintained, but was relatively low compared to that of MMP-2 during bovine gestation.
      Title: Gelatinase (MMP-2 and -9) expression profiles during gestation in the bovine endometrium.
    9. Relative expression of MMP-9 and MMP-2 increased in synovial fluid from calves with experimentally induced septic arthritis, with relative expression remaining high for several days after E. coli infection.
      Title: Relative expression of matrix metalloproteinase-2 and -9 in synovial fluid from healthy calves and calves with experimentally induced septic arthritis.
    10. In cervix, MMP9 is only active during the final cervical ripening process at parturition.
      Title: MMP-2 expression precedes the final ripening process of the bovine cervix.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in collagen catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    matrix metalloproteinase-9
    Names
    92 kDa gelatinase
    92 kDa type IV collagenase
    GELB
    MMP-9
    gelatinase B
    matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
    matrix metalloproteinase 9 (gelatinase B, 92kDa matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
    NP_777169.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174744.2 → NP_777169.1  matrix metalloproteinase-9 precursor

      See identical proteins and their annotated locations for NP_777169.1

      Status: PROVISIONAL

      Source sequence(s)
      X78324
      UniProtKB/Swiss-Prot
      A5PKB8, P52176
      UniProtKB/TrEMBL
      A0AAA9TSQ7
      Related
      ENSBTAP00000027556.5, ENSBTAT00000027556.5
      Conserved Domains (5) summary
      smart00059
      Location:340 → 388
      FN2; Fibronectin type 2 domain
      cd00094
      Location:519 → 709
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:115 → 444
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00413
      Location:115 → 444
      Peptidase_M10; Matrixin
      pfam01471
      Location:40 → 94
      PG_binding_1; Putative peptidoglycan binding domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      74746991..74754302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52176.1 GenPept UniProtKB/Swiss-Prot:P52176

    Gene LinkOut

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