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    Has1 hyaluronan synthase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 282821, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Has1provided by RGD
    Official Full Name
    hyaluronan synthase 1provided by RGD
    Primary source
    RGD:708528
    See related
    EnsemblRapid:ENSRNOG00000010994 AllianceGenome:RGD:708528
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable hyaluronan synthase activity and identical protein binding activity. Involved in estrous cycle. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in plasma membrane. Biomarker of pulmonary hypertension. Orthologous to human HAS1 (hyaluronan synthase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 15.6), Heart (RPKM 14.5) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Has1 in Genome Data Viewer
    Location:
    1q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (67366460..67378686, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (58693411..58705653, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (59720612..59732409, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene sperm acrosome associated 6 Neighboring gene microRNA 3596c Neighboring gene microRNA let-7e Neighboring gene microRNA 125a Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC108349528 Neighboring gene formyl peptide receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mycobacteria exploit host hyaluronan for efficient extracellular replication. Hirayama Y, et al. PLoS Pathog, 2009 Oct. PMID 19876387, Free PMC Article
    2. Involvement of hyaluronan synthesis in ovarian follicle growth in rats. Takahashi N, et al. Reproduction, 2014 Feb. PMID 24218629
    3. Synthesis and fragmentation of hyaluronan in renal ischaemia. Declèves AE, et al. Nephrol Dial Transplant, 2012 Oct. PMID 22529164
    4. Parallel up-regulation of FGF-2 and hyaluronan during development of cardiac hypertrophy in rat. Hellman U, et al. Cell Tissue Res, 2008 Apr. PMID 18196276
    5. Selective expression and functional characteristics of three mammalian hyaluronan synthases in oncogenic malignant transformation. Itano N, et al. J Biol Chem, 2004 Apr 30. PMID 14724275

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hyaluronan synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hyaluronan synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to platelet-derived growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in estrous cycle IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in extracellular matrix assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in extracellular matrix assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in extracellular polysaccharide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in extracellular polysaccharide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hyaluronan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hyaluronan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hyaluronan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    hyaluronan synthase 1
    NP_758826.1
    XP_038958527.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172323.2 → NP_758826.1  hyaluronan synthase 1

      See identical proteins and their annotated locations for NP_758826.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      Q8CH93
      Related
      ENSRNOP00000014824.4, ENSRNOT00000014824.6
      Conserved Domains (2) summary
      TIGR04242
      Location:51 → 493
      nodulat_NodC; chitooligosaccharide synthase NodC
      cl11394
      Location:100 → 391
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      67366460..67378686 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102599.2 → XP_038958527.1  hyaluronan synthase 1 isoform X1

      Conserved Domains (1) summary
      cl11394
      Location:100 → 362
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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