Afm afamin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Afmprovided by RGD
Official Full Name: afaminprovided by RGD
Primary source: RGD:628614
See related: EnsemblRapid:ENSRNOG00000002878 AllianceGenome:RGD:628614
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable vitamin E binding activity. Predicted to be involved in protein stabilization; protein transport within extracellular region; and vitamin transport. Located in extracellular space. Orthologous to human AFM (afamin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 2940.0) See more
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Genomic context

Location:: 14p22

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (17815194..17848042, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (17531022..17563868, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (19078678..19132212, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables vitamin E binding	IBA Inferred from Biological aspect of Ancestor more info
enables vitamin E binding	IEA Inferred from Electronic Annotation more info
enables vitamin E binding	ISO Inferred from Sequence Orthology more info
enables vitamin E binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport within extracellular region	IEA Inferred from Electronic Annotation more info
involved_in protein transport within extracellular region	ISO Inferred from Sequence Orthology more info
involved_in protein transport within extracellular region	ISS Inferred from Sequence or Structural Similarity more info
involved_in vitamin transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vitamin transport	IEA Inferred from Electronic Annotation more info
involved_in vitamin transport	ISO Inferred from Sequence Orthology more info
involved_in vitamin transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: afamin

Names: alpha-Alb; alpha-albumin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172320.2 → NP_758823.2 afamin precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

A6KKF6, G3V9R9

Related

ENSRNOP00000057275.2, ENSRNOT00000060535.6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

17815194..17848042 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039091644.2 → XP_038947572.1 afamin isoform X1

Conserved Domains (1) summary

cd00015
Location:222 → 405

ALBUMIN; Albumin domain, contains five or six internal disulphide bonds; albuminoid superfamily includes alpha-fetoprotein which binds various cations, fatty acids and bilirubin; vitamin D-binding protein which binds to vitamin D, its metabolites, and fatty acids; ...