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    PSEN1 presenilin 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 282705, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PSEN1provided by VGNC
    Official Full Name
    presenilin 1provided by VGNC
    Primary source
    VGNC:VGNC:33434
    See related
    BGD:BT10847; Ensembl:ENSBTAG00000011757
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PSEN1 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (84619645..84686876)

    Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene RNA binding motif protein 25 Neighboring gene papilin, proteoglycan like sulfated glycoprotein Neighboring gene NUMB endocytic adaptor protein Neighboring gene HEAT repeat containing 4 Neighboring gene ribosomal oxygenase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. γ-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1. Cai J, et al. J Biol Chem, 2011 Dec 9. PMID 22016384, Free PMC Article
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. gamma-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1
      Title: γ-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables aspartic endopeptidase activity, intramembrane cleaving IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables beta-catenin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cadherin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Notch receptor processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in amyloid precursor protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in amyloid-beta metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in membrane protein ectodomain proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in smooth endoplasmic reticulum calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in ciliary rootlet IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in dendritic shaft IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuromuscular junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    presenilin-1
    Names
    PS-1
    presenilin 1 (Alzheimer disease 3)
    NP_777146.1
    XP_005211988.1
    XP_005211989.1
    XP_015328710.1
    XP_059746218.1
    XP_059746219.1
    XP_059746220.1
    XP_059746221.1
    XP_059746222.1
    XP_059746223.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174721.2 → NP_777146.1  presenilin-1

      See identical proteins and their annotated locations for NP_777146.1

      Status: PROVISIONAL

      Source sequence(s)
      AF038936
      UniProtKB/Swiss-Prot
      Q9XT97
      UniProtKB/TrEMBL
      F6RMU4
      Conserved Domains (1) summary
      pfam01080
      Location:77 → 468
      Presenilin; Presenilin

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      84619645..84686876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059890236.1 → XP_059746219.1  presenilin-1 isoform X1

      UniProtKB/Swiss-Prot
      Q9XT97
      UniProtKB/TrEMBL
      F6RMU4

    2. XM_059890235.1 → XP_059746218.1  presenilin-1 isoform X1

      UniProtKB/Swiss-Prot
      Q9XT97
      UniProtKB/TrEMBL
      F6RMU4

    3. XM_059890239.1 → XP_059746222.1  presenilin-1 isoform X3

      UniProtKB/TrEMBL
      A7MBA9, F6RMU4

    4. XM_059890238.1 → XP_059746221.1  presenilin-1 isoform X2

      UniProtKB/TrEMBL
      A0AAF6ZE42, F6RMU4
      Related
      ENSBTAP00000040765.2, ENSBTAT00000043175.3

    5. XM_059890240.1 → XP_059746223.1  presenilin-1 isoform X5

      UniProtKB/TrEMBL
      A0AAF6ZSR9, F6RMU4
      Related
      ENSBTAP00000057240.2, ENSBTAT00000068561.2

    6. XM_059890237.1 → XP_059746220.1  presenilin-1 isoform X1

      UniProtKB/Swiss-Prot
      Q9XT97
      UniProtKB/TrEMBL
      F6RMU4

    7. XM_005211932.5 → XP_005211989.1  presenilin-1 isoform X1

      See identical proteins and their annotated locations for XP_005211989.1

      UniProtKB/Swiss-Prot
      Q9XT97
      UniProtKB/TrEMBL
      F6RMU4
      Conserved Domains (1) summary
      pfam01080
      Location:77 → 468
      Presenilin; Presenilin

    8. XM_005211931.5 → XP_005211988.1  presenilin-1 isoform X1

      See identical proteins and their annotated locations for XP_005211988.1

      UniProtKB/Swiss-Prot
      Q9XT97
      UniProtKB/TrEMBL
      F6RMU4
      Related
      ENSBTAP00000015615.5, ENSBTAT00000015615.6
      Conserved Domains (1) summary
      pfam01080
      Location:77 → 468
      Presenilin; Presenilin

    9. XM_015473224.3 → XP_015328710.1  presenilin-1 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1MEI7
      Related
      ENSBTAP00000069430.2, ENSBTAT00000086321.2
      Conserved Domains (1) summary
      pfam01080
      Location:67 → 458
      Presenilin; Presenilin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XT97.1 GenPept UniProtKB/Swiss-Prot:Q9XT97

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.