U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 282589, updated on 4-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    HSD11B1provided by VGNC
    Official Full Name
    hydroxysteroid 11-beta dehydrogenase 1provided by VGNC
    Primary source
    VGNC:VGNC:29965
    See related
    BGD:BT25831; Ensembl:ENSBTAG00000015086
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    11-DH; 11HSD1
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See HSD11B1 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 16 NC_037343.1 (73564340..73640701, complement)

    Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene chromosome 16 C1orf74 homolog Neighboring gene TRAF3 interacting protein 3 Neighboring gene G0/G1 switch 2 Neighboring gene laminin subunit beta 3

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Detection of 11 beta-hydroxysteroid dehydrogenase type 1, the glucocorticoid and mineralocorticoid receptor in various adipose tissue depots of dairy cows supplemented with conjugated linoleic acids. Friedauer K, et al. J Anim Physiol Anim Nutr (Berl), 2015 Oct. PMID 25354306
    2. Prostaglandin F2alpha stimulates 11Beta-hydroxysteroid dehydrogenase 1 enzyme bioactivity and protein expression in bovine endometrial stromal cells. Lee HY, et al. Biol Reprod, 2009 Apr. PMID 19109222
    3. Expression of 11beta-hydroxysteroid dehydrogenases in bovine follicle and corpus luteum. Tetsuka M, et al. J Endocrinol, 2003 Jun. PMID 12773125
    4. Gene expression of 11β-HSD and glucocorticoid receptor in the bovine (Bos taurus) follicle during follicular maturation and atresia: the role of follicular stimulating hormone. Tetsuka M, et al. J Reprod Dev, 2010 Dec. PMID 20710123
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HSD11B1 was localized in mature adipocytes of early lactating cows, indicating that circulating glucocorticoids promote effects other than differentiation.
      Title: Detection of 11 beta-hydroxysteroid dehydrogenase type 1, the glucocorticoid and mineralocorticoid receptor in various adipose tissue depots of dairy cows supplemented with conjugated linoleic acids.
    2. investigation of gene expression for 11HSD1, 11HSD2, and glucocorticoid receptor in granulosa cells and theca interna layers during follicular maturation and atresia: expression of 11HSD1 is developmentally regulated in maturing follicles
      Title: Gene expression of 11β-HSD and glucocorticoid receptor in the bovine (Bos taurus) follicle during follicular maturation and atresia: the role of follicular stimulating hormone.
    3. PGF2alpha but not PGE2 increases HSD11B1 bioactivity and protein expression by stimulating a posttranscriptional mechanism in stromal cells.
      Title: Prostaglandin F2alpha stimulates 11Beta-hydroxysteroid dehydrogenase 1 enzyme bioactivity and protein expression in bovine endometrial stromal cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 11-beta-hydroxysteroid dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in steroid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    11-beta-hydroxysteroid dehydrogenase 1
    Names
    11-beta-HSD1
    7-oxosteroid reductase
    corticosteroid 11-beta-dehydrogenase isozyme 1
    NP_001116504.1
    XP_010811843.1
    XP_059731223.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001123032.1 → NP_001116504.1  11-beta-hydroxysteroid dehydrogenase 1

      See identical proteins and their annotated locations for NP_001116504.1

      Status: PROVISIONAL

      Source sequence(s)
      AF548027
      UniProtKB/Swiss-Prot
      F6PTG3, Q8HZJ8
      Conserved Domains (1) summary
      cd05332
      Location:32 → 279
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      73564340..73640701 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010813541.4 → XP_010811843.1  11-beta-hydroxysteroid dehydrogenase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8K3KFT3
      Related
      ENSBTAP00000020078.4, ENSBTAT00000020078.5
      Conserved Domains (2) summary
      cd05332
      Location:78 → 325
      11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
      pfam00106
      Location:81 → 276
      adh_short; short chain dehydrogenase

    2. XM_059875240.1 → XP_059731223.1  11-beta-hydroxysteroid dehydrogenase 1 isoform X2

      UniProtKB/Swiss-Prot
      F6PTG3, Q8HZJ8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8HZJ8.2 GenPept UniProtKB/Swiss-Prot:Q8HZJ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials