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    PAFAH1B1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 282513, updated on 4-Oct-2024

    Summary

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    Official Symbol
    PAFAH1B1provided by VGNC
    Official Full Name
    platelet activating factor acetylhydrolase 1b regulatory subunit 1provided by VGNC
    Primary source
    VGNC:VGNC:50241
    See related
    BGD:BT13344; Ensembl:ENSBTAG00000016806
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    LIS1; MDCR; LIS-1
    Orthologs
    human mouse all
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    Genomic context

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    See PAFAH1B1 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (23512932..23581326)

    Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene MAX network transcriptional repressor Neighboring gene microRNA mir-12041 Neighboring gene methyltransferase 16, N6-methyladenosine Neighboring gene protein transport protein Sec61 subunit beta-like Neighboring gene uncharacterized LOC132343032 Neighboring gene clustered mitochondria homolog Neighboring gene coiled-coil domain containing 92B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PAFAH Ib phospholipase A2 subunits have distinct roles in maintaining Golgi structure and function. Bechler ME, et al. Biochim Biophys Acta, 2013 Mar. PMID 23262398, Free PMC Article
    2. Miller-Dieker lissencephaly gene encodes a subunit of brain platelet-activating factor acetylhydrolase [corrected]. Hattori M, et al. Nature, 1994 Jul 21. PMID 8028668
    3. LIS1 association with dynactin is required for nuclear motility and genomic union in the fertilized mammalian oocyte. Payne C, et al. Cell Motil Cytoskeleton, 2003 Dec. PMID 14584027
    4. Targeted mutagenesis of Lis1 disrupts cortical development and LIS1 homodimerization. Cahana A, et al. Proc Natl Acad Sci U S A, 2001 May 22. PMID 11344260, Free PMC Article
    5. Direct association of LIS1, the lissencephaly gene product, with a mammalian homologue of a fungal nuclear distribution protein, rNUDE. Kitagawa M, et al. FEBS Lett, 2000 Aug 11. PMID 10940388

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PAFAH Ib phospholipase A2 subunits have distinct roles in maintaining Golgi structure and function.
      Title: PAFAH Ib phospholipase A2 subunits have distinct roles in maintaining Golgi structure and function.
    2. Results suggest that LIS1 is essential to mediate genomic union in a process that involves the dynein-dynactin complex.
      Title: LIS1 association with dynactin is required for nuclear motility and genomic union in the fertilized mammalian oocyte.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC148442

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    platelet-activating factor acetylhydrolase IB subunit beta
    Names
    Miller-Dieker syndrome chromosome region
    PAF acetylhydrolase 45 kDa subunit
    PAF-AH 45 kDa subunit
    PAF-AH alpha
    PAFAH alpha
    lissencephaly-1 protein
    platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
    platelet-activating factor acetylhydrolase IB subunit alpha
    NP_777088.1
    XP_024835404.1
    XP_024835405.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174663.2 → NP_777088.1  platelet-activating factor acetylhydrolase IB subunit beta

      See identical proteins and their annotated locations for NP_777088.1

      Status: PROVISIONAL

      Source sequence(s)
      D30615
      UniProtKB/Swiss-Prot
      P43033
      UniProtKB/TrEMBL
      F6QJE8
      Related
      ENSBTAP00000068118.1, ENSBTAT00000086298.1
      Conserved Domains (5) summary
      COG2319
      Location:97 → 410
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:104 → 408
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08513
      Location:9 → 35
      LisH; LisH
      pfam10211
      Location:6 → 80
      Ax_dynein_light; Axonemal dynein light chain
      sd00039
      Location:111 → 148
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      23512932..23581326
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024979637.2 → XP_024835405.1  platelet-activating factor acetylhydrolase IB subunit beta isoform X1

      UniProtKB/TrEMBL
      A5D7P3, F6QJE8
      Conserved Domains (3) summary
      cd00200
      Location:104 → 408
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:111 → 148
      7WD40; WD40 repeat [structural motif]
      pfam08513
      Location:10 → 34
      LisH

    2. XM_024979636.2 → XP_024835404.1  platelet-activating factor acetylhydrolase IB subunit beta isoform X1

      UniProtKB/TrEMBL
      A5D7P3, F6QJE8
      Related
      ENSBTAP00000052656.4, ENSBTAT00000055329.4
      Conserved Domains (3) summary
      cd00200
      Location:104 → 408
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:111 → 148
      7WD40; WD40 repeat [structural motif]
      pfam08513
      Location:10 → 34
      LisH

    RNA

    1. XR_003030583.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43033.2 GenPept UniProtKB/Swiss-Prot:P43033

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials