PIK3R2 phosphoinositide-3-kinase regulatory subunit 2 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: PIK3R2provided by VGNC
Official Full Name: phosphoinositide-3-kinase regulatory subunit 2provided by VGNC
Primary source: VGNC:VGNC:52862
See related: BGD:BT13734; Ensembl:ENSBTAG00000002350
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	7	NC_037334.1 (5060768..5073385, complement)

Chromosome 7 - NC_037334.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:: NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data suggest a model by which NS1 activates PI3K catalytic activity by masking a normal regulatory element specific to the p85beta inter-SH2 domain.
Title: Binding of influenza A virus NS1 protein to the inter-SH2 domain of p85 suggests a novel mechanism for phosphoinositide 3-kinase activation.
insulin receptor and phosphoinositide 3-kinase in detergent-resistant membrane rafts of rod photoreceptor outer segments
Title: Localization of the insulin receptor and phosphoinositide 3-kinase in detergent-resistant membrane rafts of rod photoreceptor outer segments.
Results report that influenza A virus NS1 binds directly to p85beta, a regulatory subunit of phosphatidylinositol-3-kinase (PI3K), but not to the related p85alpha subunit.
Title: Influenza A virus NS1 protein binds p85beta and activates phosphatidylinositol-3-kinase signaling.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of phosphatidylinositol 3-kinase complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: phosphatidylinositol 3-kinase regulatory subunit beta

Names: PI3-kinase p85 subunit beta; PI3-kinase regulatory subunit beta; PI3-kinase subunit p85-beta; PI3K regulatory subunit beta; phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; phosphoinositide-3-kinase, regulatory subunit 2 (beta); phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta); phosphoinositide-3-kinase, regulatory subunit, polypeptide 2 (p85 beta); ptdIns-3-kinase p85-beta; ptdIns-3-kinase regulatory subunit beta; ptdIns-3-kinase regulatory subunit p85-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174576.2 → NP_777001.1 phosphatidylinositol 3-kinase regulatory subunit beta

See identical proteins and their annotated locations for NP_777001.1

Status: PROVISIONAL

Source sequence(s)

BC118113

UniProtKB/Swiss-Prot

P23726, Q17QY7

UniProtKB/TrEMBL

A0AAA9SRN7

Related

ENSBTAP00000086725.1, ENSBTAT00000128013.1

Conserved Domains (5) summary

cd09930
Location:611 → 713

SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

cd09942
Location:318 → 428

SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85

cd11909
Location:7 → 80

SH3_PI3K_p85beta; Src Homology 3 domain of the p85beta regulatory subunit of Class IA Phosphatidylinositol 3-kinases

cd12926
Location:433 → 593

iSH2_PIK3R2; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 2, PIK3R2, also called p85beta

cl02570
Location:110 → 292

RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...