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    GABRB1 gamma-aminobutyric acid type A receptor subunit beta1 [ Bos taurus (domestic cattle) ]

    Gene ID: 282239, updated on 4-Oct-2024

    Summary

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    Official Symbol
    GABRB1provided by VGNC
    Official Full Name
    gamma-aminobutyric acid type A receptor subunit beta1provided by VGNC
    Primary source
    VGNC:VGNC:29196
    See related
    BGD:BT22397; Ensembl:ENSBTAG00000017837
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See GABRB1 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 6 NC_037333.1 (65611892..66064698)

    Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid type A receptor subunit alpha4 Neighboring gene uncharacterized LOC132345513 Neighboring gene U6 spliceosomal RNA Neighboring gene COMM domain containing 8 Neighboring gene ATPase phospholipid transporting 10D (putative) Neighboring gene uncharacterized LOC132345514

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence and functional expression of the GABA A receptor shows a ligand-gated receptor super-family. Schofield PR, et al. Nature, 1987 Jul 16-22. PMID 3037384
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC142425

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GABA-A receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables neurotransmitter receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nervous system process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GABA-A receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gamma-aminobutyric acid receptor subunit beta-1
    Names
    GABA(A) receptor subunit beta-1
    GABAAR subunit beta-1
    gamma-aminobutyric acid (GABA) A receptor, beta 1
    gamma-aminobutyric acid type A receptor beta1 subunit
    gamma-aminobutyric-acid receptor beta 1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102374.2 → NP_001095844.1  gamma-aminobutyric acid receptor subunit beta-1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001095844.1

      Status: VALIDATED

      Source sequence(s)
      NKLS02000006
      UniProtKB/TrEMBL
      Q08DT7

    2. NM_174544.3 → NP_776969.1  gamma-aminobutyric acid receptor subunit beta-1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_776969.1

      Status: VALIDATED

      Source sequence(s)
      NKLS02000006
      UniProtKB/Swiss-Prot
      P08220
      UniProtKB/TrEMBL
      A0AAA9SL99
      Related
      ENSBTAP00000023711.5, ENSBTAT00000023711.7
      Conserved Domains (3) summary
      TIGR00860
      Location:9 → 472
      LIC; Cation transporter family protein
      pfam02931
      Location:41 → 243
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:250 → 469
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      65611892..66064698
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08220.1 GenPept UniProtKB/Swiss-Prot:P08220

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.