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    CDK5R1 cyclin dependent kinase 5 regulatory subunit 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 282173, updated on 10-Aug-2024

    Summary

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    Official Symbol
    CDK5R1provided by VGNC
    Official Full Name
    cyclin dependent kinase 5 regulatory subunit 1provided by VGNC
    Primary source
    VGNC:VGNC:27128
    See related
    BGD:BT26844; Ensembl:ENSBTAG00000004475
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    P25/P35
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See CDK5R1 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (17694835..17696848, complement)

    Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene myosin ID Neighboring gene U6 spliceosomal RNA Neighboring gene small ribosomal subunit protein eS24-like Neighboring gene proteasome 26S subunit, non-ATPase 11 Neighboring gene zinc finger protein 207

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of cdk5 in bovine brain. Ishiguro K, et al. FEBS Lett, 1994 Apr 4. PMID 8143878
    2. Precursor of cdk5 activator, the 23 kDa subunit of tau protein kinase II: its sequence and developmental change in brain. Uchida T, et al. FEBS Lett, 1994 Nov 21. PMID 7957957
    3. A brain-specific activator of cyclin-dependent kinase 5. Lew J, et al. Nature, 1994 Sep 29. PMID 8090222
    4. Alpha-chimaerin exists in a functional complex with the Cdk5 kinase in brain. Qi RZ, et al. FEBS Lett, 2004 Mar 12. PMID 15013773
    5. Microtubule association of the neuronal p35 activator of Cdk5. Hou Z, et al. J Biol Chem, 2007 Jun 29. PMID 17491008

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in brain development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of protein kinase 5 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclin-dependent kinase 5 activator 1
    Names
    CDK5 activator 1
    TPKII regulatory subunit
    cyclin-dependent kinase 5, regulatory subunit 1 (p35)
    p23
    tau protein kinase II 23 kDa subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174512.3 → NP_776937.2  cyclin-dependent kinase 5 activator 1 precursor

      See identical proteins and their annotated locations for NP_776937.2

      Status: PROVISIONAL

      Source sequence(s)
      X78934
      UniProtKB/Swiss-Prot
      Q28199
      Related
      ENSBTAP00000052270.2, ENSBTAT00000056064.4
      Conserved Domains (1) summary
      pfam03261
      Location:34 → 290
      CDK5_activator; Cyclin-dependent kinase 5 activator protein

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      17694835..17696848 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q28199.1 GenPept UniProtKB/Swiss-Prot:Q28199

    Gene LinkOut

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