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    VEGFB vascular endothelial growth factor B [ Bos taurus (domestic cattle) ]

    Gene ID: 282121, updated on 4-Oct-2024

    Summary

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    Official Symbol
    VEGFBprovided by VGNC
    Official Full Name
    vascular endothelial growth factor Bprovided by VGNC
    Primary source
    VGNC:VGNC:97324
    See related
    BGD:BT11163
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See VEGFB in Genome Data Viewer
    Location:
    chromosome: 29
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 29 NC_037356.1 (42539188..42542594)

    Chromosome 29 - NC_037356.1Genomic Context describing neighboring genes Neighboring gene tRNA phosphotransferase 1 Neighboring gene nudix hydrolase 22 Neighboring gene DnaJ heat shock protein family (Hsp40) member C4 Neighboring gene FKBP prolyl isomerase 2 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Single nucleotide polymorphisms of the bovine VEGF-B gene and their associations with growth traits in the Nanyang cattle breed. Pang YH, et al. Anim Biotechnol, 2012. PMID 23134302
    2. Placenta growth factor and vascular endothelial growth factor B and C expression in microvascular endothelial cells and pericytes. Implication in autocrine and paracrine regulation of angiogenesis. Yonekura H, et al. J Biol Chem, 1999 Dec 3. PMID 10575000
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PCR-SSCP and DNA sequencing methods were applied to reveal 3 SNPs and a duplication in the bovine VEGF-B gene among 675 samples belonging to three native Chinese cattle breeds.
      Title: Single nucleotide polymorphisms of the bovine VEGF-B gene and their associations with growth traits in the Nanyang cattle breed.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables chemoattractant activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables vascular endothelial growth factor receptor 1 binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in induction of positive chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of mast cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in vascular endothelial growth factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vascular endothelial growth factor B
    Names
    VEGF-B
    VEGF-related factor
    VRF

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174487.2 → NP_776912.1  vascular endothelial growth factor B precursor

      See identical proteins and their annotated locations for NP_776912.1

      Status: PROVISIONAL

      Source sequence(s)
      AB004273
      UniProtKB/Swiss-Prot
      Q9XS49
      Conserved Domains (1) summary
      smart00141
      Location:45 → 126
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037356.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      42539188..42542594
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024986985.2 → XP_024842753.1  vascular endothelial growth factor B isoform X1

      UniProtKB/Swiss-Prot
      Q9GLX2, Q9XS48, Q9XS49
      Conserved Domains (1) summary
      smart00141
      Location:45 → 126
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XS49.2 GenPept UniProtKB/Swiss-Prot:Q9XS49

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.