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    TMPRSS15 transmembrane serine protease 15 [ Bos taurus (domestic cattle) ]

    Gene ID: 282009, updated on 4-Oct-2024

    Summary

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    Official Symbol
    TMPRSS15provided by VGNC
    Official Full Name
    transmembrane serine protease 15provided by VGNC
    Primary source
    VGNC:VGNC:36139
    See related
    Ensembl:ENSBTAG00000000597
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    PRSS7
    Orthologs
    human mouse all
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    Genomic context

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    See TMPRSS15 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (18567977..18710975)

    Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene U6 spliceosomal RNA Neighboring gene chondrolectin Neighboring gene uncharacterized LOC132345456

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification and refolding optimization of recombinant bovine enterokinase light chain overexpressed in Escherichia coli. Tan H, et al. Protein Expr Purif, 2007 Nov. PMID 17703946
    2. Cloning and functional expression of a cDNA encoding the catalytic subunit of bovine enterokinase. LaVallie ER, et al. J Biol Chem, 1993 Nov 5. PMID 8226855
    3. The purification and characterization of bovine enterokinase from membrane fragments in the duodenal mucosal fluid. Fonseca P, et al. J Biol Chem, 1983 Dec 10. PMID 6358222
    4. Substrate specificities of porcine and bovine enteropeptidases toward the peptide Val-(Asp)4-Lys-Ile-Val-Gly and its analogs. Kim YT, et al. Biosci Biotechnol Biochem, 2008 Mar. PMID 18323639
    5. Enterokinase, the initiator of intestinal digestion, is a mosaic protease composed of a distinctive assortment of domains. Kitamoto Y, et al. Proc Natl Acad Sci U S A, 1994 Aug 2. PMID 8052624, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    enteropeptidase
    Names
    enterokinase
    protease, serine, 7 (enterokinase)
    serine protease 7
    transmembrane protease, serine 15
    NP_776864.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174439.2 → NP_776864.1  enteropeptidase precursor

      See identical proteins and their annotated locations for NP_776864.1

      Status: PROVISIONAL

      Source sequence(s)
      U09859
      UniProtKB/Swiss-Prot
      P98072
      UniProtKB/TrEMBL
      A0A452DHT9
      Related
      ENSBTAP00000068256.2, ENSBTAT00000071409.2
      Conserved Domains (9) summary
      cd06263
      Location:363 → 518
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00020
      Location:800 → 1030
      Tryp_SPc; Trypsin-like serine protease
      smart00137
      Location:358 → 518
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00200
      Location:69 → 154
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
      smart00202
      Location:694 → 784
      SR; Scavenger receptor Cys-rich
      cd00112
      Location:659 → 693
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:801 → 1032
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00431
      Location:540 → 647
      CUB; CUB domain
      cl00049
      Location:240 → 347
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      18567977..18710975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P98072.1 GenPept UniProtKB/Swiss-Prot:P98072

    Gene LinkOut

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