PDE6D phosphodiesterase 6D [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: PDE6Dprovided by VGNC
Official Full Name: phosphodiesterase 6Dprovided by VGNC
Primary source: VGNC:VGNC:32682
See related: BGD:BT12223; Ensembl:ENSBTAG00000019480
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	2	NC_037329.1 (119443675..119498744, complement)

Chromosome 2 - NC_037329.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that PrBP/delta exclusively interacts with the soluble fraction of PDE6.
Title: Mechanistic insights into the role of prenyl-binding protein PrBP/δ in membrane dissociation of phosphodiesterase 6.
The modest levels of basal activity exhibited by PDE6 purified from bovine rod outer segments (ROS) indicate that the inhibitory gamma subunit of PDE6 may not be tightly bound to PDE6 catalytic sites.
Title: Detergents stabilize the conformation of phosphodiesterase 6.
PDEdelta functions as a prenyl-binding protein interacting with multiple prenylated proteins in retinal rods.
Title: Photoreceptor cGMP phosphodiesterase delta subunit (PDEdelta) functions as a prenyl-binding protein.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Process	Evidence Code	Pubs
involved_in sensory perception of light stimulus	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

Names: GMP-PDE delta; phosphodiesterase 6D, cGMP-specific, rod, delta

NP_776845.1

EC 3.1.4.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174420.2 → NP_776845.1 retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

See identical proteins and their annotated locations for NP_776845.1

Status: PROVISIONAL

Source sequence(s)

U65073

UniProtKB/Swiss-Prot

Q95142

UniProtKB/TrEMBL

A0AAA9SR38

Related

ENSBTAP00000025947.2, ENSBTAT00000025947.4

Conserved Domains (1) summary

pfam05351
Location:10 → 149

GMP_PDE_delta; GMP-PDE, delta subunit