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    PDE5A phosphodiesterase 5A [ Bos taurus (domestic cattle) ]

    Gene ID: 281972, updated on 4-Oct-2024

    Summary

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    Official Symbol
    PDE5Aprovided by VGNC
    Official Full Name
    phosphodiesterase 5Aprovided by VGNC
    Primary source
    VGNC:VGNC:32678
    See related
    BGD:BT10779; Ensembl:ENSBTAG00000024888
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See PDE5A in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 6 NC_037333.1 (5745681..5894235)

    Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112447028 Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC112447031 Neighboring gene uncharacterized LOC112447032 Neighboring gene fatty acid binding protein 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of key amino acids in a conserved cGMP-binding site of cGMP-binding phosphodiesterases. A putative NKXnD motif for cGMP binding. Turko IV, et al. J Biol Chem, 1996 Sep 6. PMID 8703039
    2. An essential aspartic acid at each of two allosteric cGMP-binding sites of a cGMP-specific phosphodiesterase. McAllister-Lucas LM, et al. J Biol Chem, 1995 Dec 22. PMID 8530505
    3. The structure of a bovine lung cGMP-binding, cGMP-specific phosphodiesterase deduced from a cDNA clone. McAllister-Lucas LM, et al. J Biol Chem, 1993 Oct 25. PMID 8226796
    4. Zinc interactions and conserved motifs of the cGMP-binding cGMP-specific phosphodiesterase suggest that it is a zinc hydrolase. Francis SH, et al. J Biol Chem, 1994 Sep 9. PMID 8077192
    5. Substrate- and kinase-directed regulation of phosphorylation of a cGMP-binding phosphodiesterase by cGMP. Thomas MK, et al. J Biol Chem, 1990 Sep 5. PMID 2168396

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 3',5'-cyclic-GMP phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cGMP-specific 3',5'-cyclic phosphodiesterase
    Names
    CGB-PDE
    cGMP-binding cGMP-specific phosphodiesterase
    phosphodiesterase 5A, cGMP-specific
    NP_776842.1
    XP_024848769.1
    XP_024848770.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174417.2 → NP_776842.1  cGMP-specific 3',5'-cyclic phosphodiesterase

      See identical proteins and their annotated locations for NP_776842.1

      Status: PROVISIONAL

      Source sequence(s)
      L16545
      UniProtKB/Swiss-Prot
      Q28156
      Related
      ENSBTAP00000014479.4, ENSBTAT00000014479.6
      Conserved Domains (2) summary
      smart00065
      Location:154 → 311
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:602 → 837
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      5745681..5894235
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024993001.2 → XP_024848769.1  cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MRK8
      Related
      ENSBTAP00000074440.1, ENSBTAT00000075252.2
      Conserved Domains (2) summary
      smart00065
      Location:122 → 279
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:570 → 805
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    2. XM_024993002.2 → XP_024848770.1  cGMP-specific 3',5'-cyclic phosphodiesterase isoform X2

      Conserved Domains (2) summary
      smart00065
      Location:112 → 269
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:560 → 791
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q28156.1 GenPept UniProtKB/Swiss-Prot:Q28156

    Gene LinkOut

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