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    ITGB2 integrin subunit beta 2 [ Bos taurus (domestic cattle) ]

    Gene ID: 281877, updated on 10-Oct-2024

    Summary

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    Official Symbol
    ITGB2provided by VGNC
    Official Full Name
    integrin subunit beta 2provided by VGNC
    Primary source
    VGNC:VGNC:30327
    See related
    BGD:BT10874; Ensembl:ENSBTAG00000017060
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    CD18
    Orthologs
    human mouse all
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    Genomic context

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    See ITGB2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (144759519..144788699, complement)

    Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene small ubiquitin like modifier 3 Neighboring gene PTTG1 interacting protein Neighboring gene SLX9 ribosome biogenesis factor Neighboring gene uncharacterized LOC132345971 Neighboring gene uncharacterized LOC132345975

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Integrin-EGF-3 domain of bovine CD18 is critical for Mannheimia haemolytica leukotoxin species-specific susceptibility. Dileepan T, et al. FEMS Microbiol Lett, 2007 Sep. PMID 17590223
    2. Sequence of the bovine CD18-encoding cDNA: comparison with the human and murine glycoproteins. Shuster DE, et al. Gene, 1992 May 15. PMID 1351021
    3. Identification and prevalence of a genetic defect that causes leukocyte adhesion deficiency in Holstein cattle. Shuster DE, et al. Proc Natl Acad Sci U S A, 1992 Oct 1. PMID 1384046, Free PMC Article
    4. Partial genomic structure of the bovine CD18 gene and the refinement of test for bovine leukocyte adhesion deficiency. Kriegesmann B, et al. J Dairy Sci, 1997 Oct. PMID 9361228
    5. Molecular and biochemical mechanisms of Pasteurella haemolytica leukotoxin-induced cell death. Wang JF, et al. Microb Pathog, 1998 Dec. PMID 9895270

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. missense variants in the CD18 signal peptide affect Leukotoxin binding.
      Title: A bovine CD18 signal peptide variant with increased binding activity to Mannheimia hemolytica leukotoxin.
    2. Identification of numerous variations in exonic and intronic regions within the ITGB2 gene in Bos taurus and indicus screened for bovine leukocyte adhesion deficiency.
      Title: Identification of a null allele in genetic tests for bovine leukocyte adhesion deficiency in Pakistani Bos indicus × Bos taurus cattle.
    3. Intact signal peptide of CD18, the beta-subunit of beta2-integrins, renders ruminants susceptible to Mannheimia haemolytica leukotoxin.
      Title: Intact signal peptide of CD18, the beta-subunit of beta2-integrins, renders ruminants susceptible to Mannheimia haemolytica leukotoxin.
    4. Loss of CD18 is associated with bovine leukocyte adhesion deficiency.
      Title: Detection and screening of bovine leukocyte adhesion deficiency in Pakistan using molecular methods.
    5. study provides evidence that the expression of CD18 was downregulated by the plasma glycoforms of alpha-1 acid glycoprotein and inhibited the chemotaxis of monocytes
      Title: Bovine alpha-1 acid glycoprotein can reduce the chemotaxis of bovine monocytes and modulate CD18 expression.
    6. These results clearly indicate that the bovine CD18 subunit of beta(2)-integrins is the functional receptor for M. haemolytica Lkt.[ruminant-specific leukotoxin]
      Title: Monomeric expression of bovine beta2-integrin subunits reveals their role in Mannheimia haemolytica leukotoxin-induced biological effects.
    7. The I-EGF-3 domain of bovine CD18 (amino acid residues 541-581) is critical for conferring species-specific susceptibility to Mannheimia haemolytica leukotoxin.
      Title: Integrin-EGF-3 domain of bovine CD18 is critical for Mannheimia haemolytica leukotoxin species-specific susceptibility.
    8. intramammarily administered lipopolysaccharides seem to play an important role in modulating L-selectin and beta2 integrin expression on circulating bovine polymorphonuclear leukocytes
      Title: L-selectin and beta2-integrin expression on circulating bovine polymorphonuclear leukocytes during endotoxin mastitis.
    9. A delay in apoptosis was demonstrated in CD18-deficient bovine neutrophils and this appeared to be closely associated with lowered signalling via [Ca2+]i, diminished annexin V expression on the cell surface, and decreased caspase 3 activity in lysates
      Title: Decreased apoptosis of beta 2- integrin-deficient bovine neutrophils.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables amyloid-beta binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion mediated by integrin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of integrin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    integrin beta-2
    Names
    CD18 subunit
    Leu-CAM receptor
    cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
    complement receptor C3 subunit beta
    integrin, beta 2 (antigen CD18 subunit (p95), lymphocyte function-associated antigen 1, integrin B2)
    integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
    leukocyte surface protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175781.1 → NP_786975.1  integrin beta-2 precursor

      See identical proteins and their annotated locations for NP_786975.1

      Status: VALIDATED

      Source sequence(s)
      M81233
      UniProtKB/Swiss-Prot
      P32592
      UniProtKB/TrEMBL
      A0A452DIU0
      Related
      ENSBTAP00000069668.1, ENSBTAT00000076413.2
      Conserved Domains (3) summary
      smart00187
      Location:32 → 447
      INB; Integrin beta subunits (N-terminal portion of extracellular region)
      pfam07965
      Location:622 → 699
      Integrin_B_tail; Integrin beta tail domain
      pfam08725
      Location:726 → 766
      Integrin_b_cyt; Integrin beta cytoplasmic domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      144759519..144788699 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059886548.1 → XP_059742531.1  integrin beta-2 isoform X1

      UniProtKB/Swiss-Prot
      P32592
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32592.1 GenPept UniProtKB/Swiss-Prot:P32592

    Gene LinkOut

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