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    IKBKB inhibitor of nuclear factor kappa B kinase subunit beta [ Bos taurus (domestic cattle) ]

    Gene ID: 281854, updated on 4-Oct-2024

    Summary

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    Official Symbol
    IKBKBprovided by VGNC
    Official Full Name
    inhibitor of nuclear factor kappa B kinase subunit betaprovided by VGNC
    Primary source
    VGNC:VGNC:106778
    See related
    Ensembl:ENSBTAG00000007599
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See IKBKB in Genome Data Viewer
    Location:
    chromosome: 27
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 27 NC_037354.1 (37127753..37180365)

    Chromosome 27 - NC_037354.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132344067 Neighboring gene plasminogen activator, tissue type Neighboring gene uncharacterized LOC132344068 Neighboring gene uncharacterized LOC132344069 Neighboring gene DNA polymerase beta Neighboring gene dickkopf WNT signaling pathway inhibitor 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037354.1 Chromosome 27 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High glucose-induced IKK-Hsp-90 interaction contributes to endothelial dysfunction. Mohan S, et al. Am J Physiol Cell Physiol, 2009 Jan. PMID 18945937, Free PMC Article
    2. Activation of IKKbeta by glucose is necessary and sufficient to impair insulin signaling and nitric oxide production in endothelial cells. Kim F, et al. J Mol Cell Cardiol, 2005 Aug. PMID 15978611
    3. Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta. Kim F, et al. Arterioscler Thromb Vasc Biol, 2005 May. PMID 15731493
    4. Staphylococcus aureus inhibits nuclear factor kappa B activation mediated by prolactin in bovine mammary epithelial cells. Lara-Zárate L, et al. Microb Pathog, 2011 Nov. PMID 21843629
    5. Characterization of the bovine IkappaB kinases (IKK)alpha and IKKbeta, the regulatory subunit NEMO and their substrate IkappaBalpha. Rottenberg S, et al. Gene, 2002 Oct 16. PMID 12459277

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Staphylococcus aureus infection inhibits nuclear factor kappa B activation mediated by prolactin in bovine mammary epithelial cells.
      Title: Staphylococcus aureus inhibits nuclear factor kappa B activation mediated by prolactin in bovine mammary epithelial cells.
    2. Elevated levels of common free fatty acids found in human serum activate IKKbeta in bovine endothelial cells leading to reduced nitric oxide, and may serve to link pathways involved in inflammation and endothelial dysfunction.
      Title: Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta.
    3. High glucose treatment also activated IKKbeta, and pretreatment with aspirin, a pharmacological inhibitor of IKKbeta, prevented both glucose-induced IKKbeta activation and the effect of high glucose to impair insulin-mediated NO production.
      Title: Activation of IKKbeta by glucose is necessary and sufficient to impair insulin signaling and nitric oxide production in endothelial cells.
    4. High glucose-induced IKK-Hsp-90 interaction contributes to endothelial dysfunction.
      Title: High glucose-induced IKK-Hsp-90 interaction contributes to endothelial dysfunction.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables IkappaB kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of IkappaB kinase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inhibitor of nuclear factor kappa-B kinase subunit beta
    Names
    I-kappa-B kinase 2
    I-kappa-B-kinase beta
    IKK-B
    IKK-beta
    IKK2
    NFKBIKB
    inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
    inhibitor of nuclear factor kappa B kinase beta subunit
    nuclear factor NF-kappa-B inhibitor kinase beta
    serine/threonine protein kinase IKBKB
    NP_776778.1
    XP_005226156.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174353.2 → NP_776778.1  inhibitor of nuclear factor kappa-B kinase subunit beta

      See identical proteins and their annotated locations for NP_776778.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ414556
      UniProtKB/Swiss-Prot
      Q95KV0
      UniProtKB/TrEMBL
      A0AAF6YRS5
      Related
      ENSBTAP00000083835.1, ENSBTAT00000109191.1
      Conserved Domains (3) summary
      smart00220
      Location:15 → 290
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14038
      Location:20 → 309
      STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta
      pfam12179
      Location:708 → 741
      IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037354.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      37127753..37180365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005226099.5 → XP_005226156.1  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1

      UniProtKB/TrEMBL
      A0AAF6YRS5
      Conserved Domains (2) summary
      smart00220
      Location:15 → 290
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14038
      Location:20 → 309
      STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta

    RNA

    1. XR_009493068.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95KV0.1 GenPept UniProtKB/Swiss-Prot:Q95KV0

    Gene LinkOut

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