IGF2R insulin like growth factor 2 receptor [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: IGF2Rprovided by VGNC
Official Full Name: insulin like growth factor 2 receptorprovided by VGNC
Primary source: VGNC:VGNC:30082
See related: BGD:BT10008; Ensembl:ENSBTAG00000002402
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: CIMPR; CI-MPR
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 48

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	9	NC_037336.1 (96197493..96300019)

Chromosome 9 - NC_037336.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037336.1 Chromosome 9 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genomic imprinting of the IGF2R/AIR locus is conserved between bovines and mice.
Title: Genomic imprinting of the IGF2R/AIR locus is conserved between bovines and mice.
Components of the insulin-like growth factor system in in vivo - and in vitro-derived fetuses of cattle, and the association with growth and development.
Title: Components of the insulin-like growth factor system in in vivo - and in vitro-derived fetuses of cattle, and the association with growth and development.
Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments.
Title: Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments.
Here we examined the transcriptome of skeletal muscle, liver, kidney, and brain of control and LOS bovine fetuses and found that different tissues within LOS fetuses have perturbations of distinct gene pathways... only a small percent of differentially expressed genes (DEGs), including the imprinted gene IGF2R, could be associated with the neighboring differentially methylated regions
Title: Global misregulation of genes largely uncoupled to DNA methylome epimutations characterizes a congenital overgrowth syndrome.
suggest that the insulin like growth factor 2 receptor(IGF2R) gene polymorphisms could be useful genetic markers for dairy production traits in cattle
Title: Association of SNP and STR polymorphisms of insulin-like growth factor 2 receptor (IGF2R) gene with milk traits in Holstein-Friesian cows.
study hypothesizes that reduced granulosa cell insulin-like growth factor II receptor expression in F2 follicles of Twinner cows may play a role in the development of 2 or more dominant follicles
Title: Possible role of IGF2 receptors in regulating selection of 2 dominant follicles in cattle selected for twin ovulations and births.
imprinting of Bos taurus IGF2R is similar to mouse except in placenta, which could indicate an effect of reproductive strategy
Title: Tissue-specific and minor inter-individual variation in imprinting of IGF2R is a common feature of Bos taurus Concepti and not correlated with fetal weight.
Increases in CYP19A1 and FSHR mRNA expression and decreases in IGF2R mRNA expression in follicles of Twinners support the hypothesis that increased follicular development and steroidogenesis result from increased extra-ovarian IGF-1 production.
Title: Increased abundance of aromatase and follicle stimulating hormone receptor mRNA and decreased insulin-like growth factor-2 receptor mRNA in small ovarian follicles of cattle selected for twin births.
Sex-sorting procedure by flow cytometry did not affect the overall DNA methylation patterns of the IGF2 and IGF2R genes, although individual variation in their methylation patterns among bulls was observed.
Title: The methylation patterns of the IGF2 and IGF2R genes in bovine spermatozoa are not affected by flow-cytometric sex sorting.
Study demonstrates associations between IGF2R polymorphisms and growth- and body-related traits in cattle.
Title: Single nucleotide polymorphisms in the imprinted bovine insulin-like growth factor 2 receptor gene (IGF2R) are associated with body size traits in Irish Holstein-Friesian cattle.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables D-mannose binding	IEA Inferred from Electronic Annotation more info	PubMed
enables insulin-like growth factor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in lysosomal transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in late endosome	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in trans-Golgi network	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cation-independent mannose-6-phosphate receptor

Names: 300 kDa mannose 6-phosphate receptor; CI Man-6-P receptor; IGF-II receptor; M6PR; MPR 300; insulin-like growth factor II receptor; insulin-like growth factor receptor type 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174352.2 → NP_776777.1 cation-independent mannose-6-phosphate receptor precursor

See identical proteins and their annotated locations for NP_776777.1

Status: PROVISIONAL

Source sequence(s)

AF342811

UniProtKB/Swiss-Prot

P08169

UniProtKB/TrEMBL

F1MIE6

Related

ENSBTAP00000037502.4, ENSBTAT00000037678.4

Conserved Domains (3) summary

smart00059
Location:1906 → 1951

FN2; Fibronectin type 2 domain

pfam00878
Location:1331 → 1471

CIMR; Cation-independent mannose-6-phosphate receptor repeat

cl39051
Location:649 → 772

ATG27; Autophagy-related protein 27