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    HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 281824, updated on 4-Oct-2024

    Summary

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    Gene symbol
    HSD3B1
    Gene description
    hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
    See related
    BGD:BT11769; Ensembl:ENSBTAG00000006769
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    HSD3B
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    Genomic context

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    See HSD3B1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (23706726..23716623, complement)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene phosphoglycerate dehydrogenase Neighboring gene uncharacterized LOC112445962 Neighboring gene zinc finger protein 697 Neighboring gene hydroxyacid oxidase 2 Neighboring gene uncharacterized LOC132344986

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Light and electron microscopic immunohistochemistry of the localization of adrenal steroidogenic enzymes. Ishimura K, et al. Microsc Res Tech, 1997 Mar 15. PMID 9142691
    2. Molecular cloning, cDNA structure and predicted amino acid sequence of bovine 3 beta-hydroxy-5-ene steroid dehydrogenase/delta 5-delta 4 isomerase. Zhao HF, et al. FEBS Lett, 1989 Dec 18. PMID 2599102
    3. Isolation and amino acid sequence analysis of bovine adrenal 3 beta-hydroxysteroid dehydrogenase/steroid isomerase. Rutherfurd KJ, et al. Biochemistry, 1991 Aug 20. PMID 1868086
    4. Assignment of the bovine PTGFR and HSD3B1 genes to bovine chromosome 3 with somatic and radiation hybrid panel mapping. Nakata LC, et al. Cytogenet Genome Res, 2006. PMID 16717461
    5. The pre-ovulatory luteinizing hormone surge is followed by down-regulation of CYP19A1, HSD3B1, and CYP17A1 and chromatin condensation of the corresponding promoters in bovine follicles. Nimz M, et al. Mol Reprod Dev, 2010 Dec. PMID 21069797

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Granulosa and theca of well-characterized large bovine follicles were isolated before and after the LH surge. CYP19A1, HSD3B1, and CYP17A1 transcripts were quantified by real-time PCR (qPCR) and the chromatin condensation was determined.
      Title: The pre-ovulatory luteinizing hormone surge is followed by down-regulation of CYP19A1, HSD3B1, and CYP17A1 and chromatin condensation of the corresponding promoters in bovine follicles.
    2. Serum free culture conditions significantly enhanced Cyp17 and Csh1 but not Hsd3b expression in trophoblast.
      Title: Cultured bovine trophoblast cells differentially express genes encoding key steroid synthesis enzymes.
    3. Mapped bo bovine chromosome 3
      Title: Assignment of the bovine PTGFR and HSD3B1 genes to bovine chromosome 3 with somatic and radiation hybrid panel mapping.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
    Names
    3-beta-HSD
    hydroxy-delta-MAY-steroid dehydrogenase, 3 beta- and steroid delta-isomerase
    NP_776768.1
    XP_010801405.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174343.3 → NP_776768.1  3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase

      See identical proteins and their annotated locations for NP_776768.1

      Status: PROVISIONAL

      Source sequence(s)
      X17614
      UniProtKB/Swiss-Prot
      P14893, Q2T9Y8
      Related
      ENSBTAP00000086603.1, ENSBTAT00000106839.1
      Conserved Domains (2) summary
      pfam01073
      Location:7 → 287
      3Beta_HSD; 3-beta hydroxysteroid dehydrogenase/isomerase family
      cl21454
      Location:5 → 357
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      23706726..23716623 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010803103.4 → XP_010801405.1  3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase isoform X1

      UniProtKB/TrEMBL
      A0A452DIY6
      Related
      ENSBTAP00000010992.6, ENSBTAT00000010992.6
      Conserved Domains (1) summary
      cl21454
      Location:29 → 338
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14893.2 GenPept UniProtKB/Swiss-Prot:P14893

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.