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    GNAS GNAS complex locus [ Bos taurus (domestic cattle) ]

    Gene ID: 281793, updated on 12-Oct-2024

    Summary

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    Official Symbol
    GNASprovided by VGNC
    Official Full Name
    GNAS complex locusprovided by VGNC
    Primary source
    VGNC:VGNC:108130
    See related
    BGD:BT12337; Ensembl:ENSBTAG00000047223 Ensembl:ENSBTAG00000052413
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    SCG6; GNAS1; NESP55
    Orthologs
    human mouse all
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    Genomic context

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    See GNAS in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (57465317..57532620, complement)

    Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene cathepsin Z Neighboring gene negative elongation factor complex member C/D Neighboring gene uncharacterized LOC132346936 Neighboring gene uncharacterized LOC101909083 Neighboring gene uncharacterized LOC107133071 Neighboring gene microRNA mir-6123 Neighboring gene microRNA mir-296

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Galpha(s) is palmitoylated at the N-terminal glycine. Kleuss C, et al. EMBO J, 2003 Feb 17. PMID 12574119, Free PMC Article
    2. Molecular basis for two forms of the G protein that stimulates adenylate cyclase. Robishaw JD, et al. J Biol Chem, 1986 Jul 25. PMID 3015900
    3. Primary structure of the alpha-subunit of bovine adenylate cyclase-stimulating G-protein deduced from the cDNA sequence. Nukada T, et al. FEBS Lett, 1986 Jan 20. PMID 3080331
    4. Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase. Robishaw JD, et al. Proc Natl Acad Sci U S A, 1986 Mar. PMID 3081893, Free PMC Article
    5. Crystal structure of the adenylyl cyclase activator Gsalpha. Sunahara RK, et al. Science, 1997 Dec 12. PMID 9395396

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound beta1-Adrenergic Receptor.
      Title: Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound β(1)-Adrenergic Receptor.
    2. application of peptide amide hydrogen-deuterium exchange mass spectrometry to probe changes in the structure of the heterotrimeric bovine G protein, Gs on formation of a complex with agonist-bound human beta(2) adrenergic receptor
      Title: Conformational changes in the G protein Gs induced by the β2 adrenergic receptor.
    3. crystal structure of the active state ternary complex composed of agonist-occupied monomeric beta2 adrenergic receptor and nucleotide-free Gs heterotrimer
      Title: Crystal structure of the β2 adrenergic receptor-Gs protein complex.
    4. the results presented here indicate an important role for the imprinted GNAS cluster in underlying complex
      Title: DNA sequence polymorphisms within the bovine guanine nucleotide-binding protein Gs subunit alpha (Gsα)-encoding (GNAS) genomic imprinting domain are associated with performance traits.
    5. a nucleotide-free state of Galphas is induced by Cu2+ and Zn2+
      Title: Copper and zinc inhibit Galphas function: a nucleotide-free state of Galphas induced by Cu2+ and Zn2+.
    6. maternally expressed like its counterparts in mouse and human
      Title: Imprinting of Nesp55 gene in cattle.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC148689, MGC152036

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables D1 dopamine receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables G-protein beta/gamma-subunit complex binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables beta-2 adrenergic receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables corticotropin-releasing hormone receptor 1 binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables insulin-like growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ionotropic glutamate receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables mu-type opioid receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating dopamine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to parathyroid hormone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sensory perception of chemical stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of heterotrimeric G-protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GNAS complex locus; SCG6 (secretogranin VI)
    Names
    adenylate cyclase-stimulating G alpha protein
    guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1
    neuroendocrine secretory protein 55
    secretogranin VI
    stimulatory G-protein alpha subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271771.1 → NP_001258700.1  SCG6 (secretogranin VI) isoform SCG6 precursor

      See identical proteins and their annotated locations for NP_001258700.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) is maternally expressed and encodes secretogranin VI (SCG6, also known as NESP55), which localizes to large secretory vesicles of endocrine cells and neurons. Its coding region is within the 5'-most exon and does not overlap the coding regions used by other transcripts; thus SCG6 has no similarity to isoforms of the G-protein alpha subunit. This variant has an antisense transcript, GNAS-AS1.
      Source sequence(s)
      BC102905, DV819537, DV875704, DV882459
      UniProtKB/Swiss-Prot
      O18979
      Conserved Domains (1) summary
      pfam06390
      Location:1 → 241
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

    2. NM_181021.3 → NP_851364.1  GNAS complex locus isoform GNASL

      See identical proteins and their annotated locations for NP_851364.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is biallelically expressed and encodes guanine nucleotide binding protein alpha s long (GNASL), also known as alpha-S2, a form of the G-protein alpha subunit.
      Source sequence(s)
      BC122757
      UniProtKB/Swiss-Prot
      P04896, Q0II85, Q3SZE7
      UniProtKB/TrEMBL
      A0AAA9TCZ2
      Related
      ENSBTAP00000094718.1, ENSBTAT00000112874.1
      Conserved Domains (1) summary
      cd00066
      Location:41 → 388
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      57465317..57532620 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059892388.1 → XP_059748371.1  GNAS complex locus isoform X13

    2. XM_059892385.1 → XP_059748368.1  GNAS complex locus isoform X4

    3. XM_059892384.1 → XP_059748367.1  GNAS complex locus isoform X3

      UniProtKB/TrEMBL
      A0AAA9TK99
      Related
      ENSBTAP00000097346.1, ENSBTAT00000110331.1

    4. XM_059892383.1 → XP_059748366.1  GNAS complex locus isoform X2

    5. XM_059892382.1 → XP_059748365.1  GNAS complex locus isoform X1

      UniProtKB/TrEMBL
      A0AAF6DLW9
      Related
      ENSBTAP00000023246.7, ENSBTAT00000023246.7

    6. XM_025000300.2 → XP_024856068.1  GNAS complex locus isoform X11

      Conserved Domains (1) summary
      cd00066
      Location:1 → 314
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    7. XM_059892387.1 → XP_059748370.1  GNAS complex locus isoform X10

    8. XM_025000297.2 → XP_024856065.1  GNAS complex locus isoform X9

      Conserved Domains (1) summary
      cd00066
      Location:1 → 329
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    9. XM_059892386.1 → XP_059748369.1  GNAS complex locus isoform X8

    10. XM_025000296.2 → XP_024856064.1  GNAS complex locus isoform X7

      UniProtKB/TrEMBL
      A0AAA9TCZ2
      Conserved Domains (1) summary
      cd00066
      Location:41 → 373
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    11. XM_025000295.2 → XP_024856063.1  GNAS complex locus isoform X6

      UniProtKB/TrEMBL
      A0AAA9TCZ2
      Conserved Domains (1) summary
      cd00066
      Location:41 → 374
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    12. XM_025000294.2 → XP_024856062.1  GNAS complex locus isoform X5

      UniProtKB/TrEMBL
      A0AAA9TCZ2, A0AAF7AP21
      Related
      ENSBTAP00000072381.2, ENSBTAT00000070189.2
      Conserved Domains (1) summary
      cd00066
      Location:41 → 389
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    13. XM_025000303.2 → XP_024856071.1  SCG6 (secretogranin VI) isoform X12

      UniProtKB/TrEMBL
      A6QPC1, F1N0T0
      Related
      ENSBTAP00000054341.2, ENSBTAT00000064670.3
      Conserved Domains (1) summary
      pfam06390
      Location:1 → 241
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O18979.1 GenPept UniProtKB/Swiss-Prot:O18979
    P04896.1 GenPept UniProtKB/Swiss-Prot:P04896

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